Gene Report

Basic Information

Approved Symbol	MBNL2
Approved Name	muscleblind-like splicing regulator 2
Previous Name	muscleblind-like 2 (Drosophila)
Symbol Alias	MBLL, MBLL39
Location	13q31.1
Position	chr13:97874550-98046374 (+)
External Links	Entrez Gene: 10150 Ensembl: ENSG00000139793 UCSC: uc001vmz.3 HGNC ID: 16746
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between MBNL2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
MBNL2	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.001, F=11.2; Substance: P-value=0.006, F=9.8	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationships between MBNL2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
MBNL2		Suicide(suicide)	symptoms	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.001, F=11.2; Substance: P-value=0.006, F=9.8	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationship network of MBNL2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between MBNL2 and MDD (count: 0)

Negative relationships between MBNL2 and other components at different levels (count: 0)

MBNL2 related SNPs in MK4MDD (count: 0)

MBNL2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Muscleblind-like protein 2	Q5VZF2	0(0/0)	Gene mapped

MBNL2 related GO terms (count: 8)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0008380	RNA splicing	biological process	IEA
GO:0005634	nucleus	cellular component	IEA
GO:0003723	RNA binding	molecular function	IEA
GO:0006397	mRNA processing	biological process	IEA
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	biological process	IEA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0005737	cytoplasm	cellular component	IEA
GO:0043484	regulation of RNA splicing	biological process	IDA[16946708]

MBNL2 related KEGG pathways (count: 0)

MBNL2 related BioCarta pathways (count: 0)

MBNL2 related Reactome pathways (count: 0)

MBNL2 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms