Study Report
Reference
| Citation | Lee, 2006 PubMed |
| Full Info | Lee, B.H., Lee, S.W., Yoon, D., Lee, H.J., Yang, J.C., Shim, S.H., Kim, D.H., Ryu, S.H., Han, C. and Kim, Y.K. (2006) Increased plasma nitric oxide metabolites in suicide attempters. Neuropsychobiology, 53, 127-132.
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Study
| Hypothesis or Background |
To evaluate any correlation between plasma levels of nitric oxide metabolites (NO(x)) and suicide attempt.
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| Sample Information | 53 patients who had recently attempted suicide, 58 non-suicidal psychiatric patients, and 75 normal controls |
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| Method Detail | Plasma NO(x) levels were measured in 53 patients who had recently attempted suicide, 58 non-suicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale. |
| Method Keywords | blood analysis |
| Result | Plasma NO(x) levels were significantly higher in suicidal patients than non-suicidal psychiatric patients or normal control subjects (F=11.029, d.f.=2, 183, p<0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003). |
| Conclusions | Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients. |
Relationships reported by
Lee, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Nitric oxide (nitric oxide) |
molecule |
t=-3.090, d.f.=84, P-value=0.003 |
Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma nitric oxide metabolites NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003). |
Positive
|
|
Suicide (suicide)
|
symptoms |
Nitric oxide (nitric oxide) |
molecule |
t=-3.090, d.f.=84, P-value=0.003 |
Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma nitric oxide metabolites NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003). |
Positive
|
