MK4MDD

Symptoms Report

Basic Information
Name Irritability
Description "Irritability is an excessive response to stimuli. The term is used for both the physiological reaction to stimuli and for the pathological, abnormal or excessive sensitivity to stimuli; It is usually used to refer to anger or frustration. Irritability may be demonstrated in behavioral responses to both physiological and behavioral stimuli including environmental, situational, sociological, and emotional stimuli."
No. of Studies (Positive/Negative) 21 (21/0) Help

Positive relationship between Irritability and MDD (count: 11)
Name in Literature Reference Research Type Statistical Result Relation Description Help
irritability Luby, 2003 normal people Anhedonia appeared to be a specific symptom and sadness/irri...... Anhedonia appeared to be a specific symptom and sadness/irritability appeared to be a sensitive symptom of preschool MDD. More...
aggressiveness Pasquini, 2004 patients only 21.60% The anger/irritability dimension was clinically relevant in ...... The anger/irritability dimension was clinically relevant in 23% of patients. Anger/aggressiveness was especially frequent (21.6%), whereas psychomotor activation was infrequent (0.9%). More...
irritability Pasquini, 2004 patients only 23% of patients The anger/irritability dimension was clinically relevant in ...... The anger/irritability dimension was clinically relevant in 23% of patients. More...
behavior symptoms like anger and aggression Krishnakumar, 2006 patients only Children with depressive disorder had significantly more fam...... Children with depressive disorder had significantly more family members affected with mental illnesses. The clinical features included diminished interest in play and activities, excessive tiredness, low self- esteem, problems with concentration, multiple somatic complaints, behavior symptoms like anger and aggression, recent deterioration in school performance and suicidal behavior. More...
irritability Fu, 2008 patients only 58.60% The most common depressive symptoms were: anhedonia (72.4%),...... The most common depressive symptoms were: anhedonia (72.4%), depressed mood (72.4%), decreased concentration (62.1%), and irritability (58.6%). More...
aggression Hurley, 2008 patients and normal controls for depressed patients, aggression and impulsivity were sign...... for depressed patients, aggression and impulsivity were significant compared with anxiety patients and controls. More...
impulsivity Hurley, 2008 patients and normal controls for depressed patients, aggression and impulsivity were sign...... for depressed patients, aggression and impulsivity were significant compared with anxiety patients and controls. More...
irritability Perlis, 2009 patients only Irritable depression is not a distinct subtype of MDD, but i...... Irritable depression is not a distinct subtype of MDD, but irritability is associated with greater overall severity, anxiety comorbidity and suicidality. More...
irritability Fava, 2010 patients only Irritability was especially common in MDD among respondents ...... Irritability was especially common in MDD among respondents in the age range 18-44 and students. More...
irritability Stringaris, 2009 normal people odds ratio=1.33, 95% confidence interval [CI]=1.00-1.78 After adjustment for baseline emotional and behavioral disor...... After adjustment for baseline emotional and behavioral disorders, irritability in adolescence predicted major depressive disorder (odds ratio=1.33, 95% confidence interval [CI]=1.00-1.78]) at 20-year follow-up. More...
impulsivity Maalouf, 2011 patients and normal controls P-value = 0.01, d = 0.85 and P-value = 0.008, d = 0.49 respectively MDDa showed more impulsivity as measured by lower response b...... MDDa showed more impulsivity as measured by lower response bias (B¡å) on a sustained attention task than both MDDr and HC (p=0.01, d=0.85 and p=0.008, d=0.49 respectively). More...

Positive relationships between Irritability and other components at different levels (count: 21) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Irritability in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Irritability and MDD (count: 0)
Negative relationships between Irritability and other components at different levels (count: 0) Help