Molecule Report

Basic Information

Name	Dopamine
Description	One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors ( RECEPTORS, DOPAMINE) mediate its action
MeSH ID	D004298
No. of Studies (Positive/Negative)	8(8/0)

Positive relationship between Dopamine and MDD (count: 4)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
dopamine	Agren, 1994	patients and normal controls		Decreased uptake of [11C]L-DOPA (the direct precursors in th...... Decreased uptake of [11C]L-DOPA (the direct precursors in the synthetic pathways to dopamine) over the blood-brain barrier in depression (which is not altered by dietary tryptophan depletion in healthy volunteers). More...
dopamine	Meyer, 2001	patients and normal controls		Low striatal dopamine transporter binding potential (DAT BP)...... Low striatal dopamine transporter binding potential (DAT BP) in major depressive episodes is consistent with a downregulation of DAT (dopamine transporter) in response to a dopamine lowering process. More...
dopamine	Montgomery, 2007	patients and normal controls		[(11)C]raclopride binding was reduced in the dorsal striatum...... [(11)C]raclopride binding was reduced in the dorsal striatum of people taking antidepressants suggesting that dopamine release was increased, compared to untreated controls. More...
dopamine	Brody, 2009	patients and normal controls	P-value=0.036	Dopamine release (measured indirectly as change in (11)C-rac...... Dopamine release (measured indirectly as change in (11)C-raclopride binding potential [BP(ND)]). The MDD+ group had a significantly greater reduction in (11)C-raclopride BP(ND) (-16.3%) than the MDD- group (-8.4%) (analysis of covariance [ANCOVA], p = .03). More...

Positive relationships between Dopamine and other components at different levels (count: 8)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
dopamine		Sodium-dependent dopamine transporter(dopamine transporter)	protein	Meyer, 2001	patients and normal controls	Lower dopamine transporter binding potential (DAT BP) itself...... Lower dopamine transporter binding potential (DAT BP) itself reduces extracellular clearance of dopamine. More...
dopamine		Leptin receptor(leptin receptor (Lepr))	protein	Liu J, 2011	animal model	expressed on expressed on
dopamine		Caudate nucleus(ipsilateral caudate nucleus)	brain morphology and function	Strafella, 2001	normal people	Repetitive transcranial magnetic stimulation (rTMS) of the p...... Repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex induces the release of endogenous dopamine in the ipsilateral caudate nucleus. More...
dopamine		Caudate nucleus(ipsilateral caudate nucleus)	brain morphology and function	Strafella, 2003	normal people	We have shown previously that repetitive transcranial magnet...... We have shown previously that repetitive transcranial magnetic stimulation (rTMS) of the human prefrontal cortex led to focal dopamine release in the ipsilateral caudate nucleus, supporting the corticostriatal mode of dopamine release. More...
dopamine		Striatum(striatum)	brain morphology and function	Montgomery, 2007	patients and normal controls	[(11)C]raclopride binding was reduced in the dorsal striatum...... [(11)C]raclopride binding was reduced in the dorsal striatum of people taking antidepressants suggesting that dopamine release was increased, compared to untreated controls. More...
dopamine		Temporal Lobe(temporal cortices)	brain morphology and function	Lehto, 2008	patients and normal controls	Dopaminergic abnormalities may be present in the temporal co...... Dopaminergic abnormalities may be present in the temporal cortices of major depressives. More...
dopamine		Anxiety-like behaviors from animal model(anxiety-like behavior)	cognition and behavior	Liu J, 2011	animal model	Blockade of D1-dependent dopamine transmission in the centra...... Blockade of D1-dependent dopamine transmission in the central amygdala by local microinjection of the D1 antagonist SCH23390 attenuated the anxiogenic phenotype of Lepr(DAT-Cre) mice More...
dopamine		Irritability(increased irritability)	symptoms	Liu J, 2011	animal model	Blockade of D1-dependent dopamine transmission in the centra...... Blockade of D1-dependent dopamine transmission in the central amygdala by local microinjection of the D1 antagonist SCH23390 attenuated the anxiogenic phenotype of Lepr(DAT-Cre) mice More...

Positive relationship network of Dopamine in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationship between Dopamine and MDD (count: 0)

Negative relationships between Dopamine and other components at different levels (count: 0)