Protein Report

Basic Information

Protein Name	Prolactin
UniPortKB	P01236
No. of Studies (Positive/Negative)	5 (5/0)
Type	Literature-origin

Positive relationship between Prolactin and MDD (count: 3)

Name in Literature	Reference	Research Type	Relation Description
prolactin	Sher, 2003	patients and normal controls	We found a trend towards a blunted prolactin response in dep...... We found a trend towards a blunted prolactin response in depressed patients compared to healthy controls More...
prolactin	Koenigsberg, 2004	patients and normal controls	The depressed patients had phase advanced circadian rhythms ...... The depressed patients had phase advanced circadian rhythms for cortisol, norepinephrine and MHPG, phase advanced hemicircadian rhythms for cortisol and prolactin, and a phase advanced ultradian rhythm for prolactin compared to healthy control subjects. More...
prolactin	Kiive, 2004	patients and normal controls	prolactin levels increased only in the depressed patients gr...... prolactin levels increased only in the depressed patients group during the exercise More...

Positive relationships between Prolactin and other components at different levels (count: 3)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
prolactin		Irritability(aggression and impulsivity)	symptoms	Sher, 2003	patients and normal controls		We also found a negative correlation between aggression and ...... We also found a negative correlation between aggression and impulsivity scores and prolactin responses in subgroup with unipolar but not bipolar depression. More...
prolactin		Psychotic symptoms(dissociative symptoms)	symptoms	Bob, 2007	patients only	r=0.52, P-value=0.004	Data show that prolactin manifests significant relationship ...... Data show that prolactin manifests significant relationship to dissociative symptoms (r=0.52, p=0.004). More...
prolactin		Psychotic symptoms(dissociative symptoms)	symptoms	Bob, 2008	patients only		The results show that prolactin and cortisol as indices of H...... The results show that prolactin and cortisol as indices of HPA axis functioning manifest significant relationship to dissociative symptoms. More...

Positive relationship network of Prolactin in MK4MDD

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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Prolactin and MDD (count: 0)

Negative relationships between Prolactin and other components at different levels (count: 0)

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
PRL	prolactin	Protein mapped	0 (0/0)