Gene Report

Basic Information

Approved Symbol	SCD
Approved Name	stearoyl-CoA desaturase (delta-9-desaturase)
Previous Symbol	SCDOS
Previous Name	stearoyl-CoA desaturase opposite strand
Symbol Alias	FADS5
Name Alias	acyl-CoA desaturase, "fatty acid desaturase", "delta-9-desaturase"
Location	10q23-q24
Position	chr10:102106772-102124588 (+)
External Links	Entrez Gene: 6319 Ensembl: ENSG00000099194 UCSC: uc001kqy.3 HGNC ID: 10571
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SCD and MDD (count: 0)

Positive relationships between SCD and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
stearoyl-CoA desaturase (SCD)		Suicide(suicide attempt)	symptoms	Lalovic, 2010	patients and normal controls		Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp...... Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects More...

Positive relationship network of SCD in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SCD and MDD (count: 0)

Negative relationships between SCD and other components at different levels (count: 0)

SCD related SNPs in MK4MDD (count: 0)

SCD related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Acyl-CoA desaturase	O00767	0(0/0)	Gene mapped

SCD related GO terms (count: 6)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006633	fatty acid biosynthetic process	biological process	IEA
GO:0005506	iron ion binding	molecular function	IEA
GO:0005783	endoplasmic reticulum	cellular component	IDA
GO:0004768	stearoyl-CoA 9-desaturase activity	molecular function	IEA
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA
GO:0016021	integral to membrane	cellular component	IEA

SCD related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa01040	biosynthesis of_unsaturated_fatty_acids	Biosynthesis of unsaturated fatty acids
hsa03320	ppar signaling_pathway	PPAR signaling pathway	Peroxisome proliferator-activated receptors (PPARs) are nucl...... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. More...

SCD related BioCarta pathways (count: 0)

SCD related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19241	regulation of_lipid_metabolism_by_peroxisome_proliferator_activated_receptor_alpha	Peroxisome proliferator-activated receptor alpha (PPAR-alpha...... Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma lipid levels. PPAR-alpha is a type II nuclear receptor (its subcellular location does not depend on ligand binding). PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha), another type II nuclear receptor. PPAR-alpha is activated by binding fatty acid ligands, especially polyunsaturated fatty acids having 18-22 carbon groups and 2-6 double bonds. The PPAR-alpha:RXR-alpha heterodimer binds peroxisome proliferator receptor elements (PPREs) in and around target genes. Binding of fatty acids and synthetic ligands causes a conformational change in PPAR-alpha such that it releases the corepressors and binds coactivators (CBP-SRC-HAT complex, ASC complex, and TRAP-Mediator complex) which initiate transcription of the target genes. Target genes of PPAR-alpha participate in fatty acid transport, fatty acid oxidation, triglyceride clearance, lipoprotein production, and cholesterol homeostasis. More...
REACT_602	metabolism of_lipids_and_lipoproteins	Lipids are hydrophobic but otherwise chemically diverse mole...... Lipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphingolipids, eicosanoids, cholesterol, bile salts, steroid hormones, and fat-soluble vitamins, and function as a major source of energy (fatty acids, triacylglycerols, and ketone bodies), are major constituents of cell membranes (cholesterol and phospholipids), play a major role in their own digestion and uptake (bile salts), and participate in numerous signaling and regulatory processes (steroid hormones, eicosanoids, and sphingolipids). Because of their poor solubility in water, most lipids in extracellular spaces in the human body are found as complexes with specific carrier proteins. Regulation of the formation and movement of these lipoprotein complexes is a critical aspect of human lipid metabolism, and lipoprotein abnormalities are associated with major human disease processes including atherosclerosis and diabetes. Aspects of lipid metabolism currently annotated in Reactome include lipid digestion, trafficking of dietary sterols, triacylglycerol synthesis (fatty acid synthesis and triacylglycerol assembly), hormone-sensitive lipase-mediated triacylglycerol breakdown, and beta-oxidation of fatty acids, ketone body metabolism (synthesis and utilization), the synthesis of cholesterol, bile salts, and steroid hormones, and sphingolipid metabolism. Three aspects of lipoprotein function are currently annotated: chylomicron-mediated lipid transport, HDL (high density lipoprotein)-mediated lipid transport, and LDL (low density lipoprotein) endocytosis and degradation. More...

SCD related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways