Study Report
Reference
| Citation | Miguel-Hidalgo, 2011 PubMed |
| Full Info | Miguel-Hidalgo, J.J., Overholser, J.C., Jurjus, G.J., Meltzer, H.Y., Dieter, L., Konick, L., Stockmeier, C.A. and Rajkowska, G. (2011) Vascular and extravascular immunoreactivity for intercellular adhesion molecule 1 in the orbitofrontal cortex of subjects with major depression: Age-dependent changes. J Affect Disord, 132, 422-431.
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Study
| Hypothesis or Background |
Vascular and immune alterations in the prefrontal cortex may contribute to major depression in elderly subjects. Intercellular adhesion molecule-1 (ICAM-1), major inflammatory mediator in vessels and astrocytes, could be altered in geriatric depression, but little is known about its age-dependent expression in subjects with depression and its relationship to astrocytes identified by the marker glial fibrillary acidic protein (GFAP), found to be reduced in depression.
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| Sample Information | 19 non-psychiatric comparison subjects and 18 subjects with major depression |
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| Method Detail | We measured the percentage of gray matter area fraction covered by ICAM-1 immunoreactivity in blood vessels and in extravascular accumulations of ICAM-1 immunoreactivity in 19 non-psychiatric comparison subjects and 18 subjects with major depression, all characterized by postmortem psychological diagnosis. Association of extravascular ICAM-1 to GFAP-positive astrocytes was investigated by double-labeling immunofluorescence. |
| Method Keywords | postmortem study |
| Result | Vascular and extravascular fractions of ICAM-1 immunoreactivity were lower in subjects with MDD than in non-psychiatric comparison subjects. Non-psychiatric comparison subjects older than 60 experienced dramatic increase in extravascular ICAM-1 immunoreactivity, but this increase was attenuated in elderly subjects with MDD, particularly in those dying by suicide. Most extracellular ICAM-1 immunoreactivity was coextensive with GFAP-immunoreactive astrocytes in both groups. |
| Conclusions | There is significant attenuation of extravascular and vascular ICAM-1 immunoreactivity in elderly subjects with major depression suggesting an astrocyte-associated alteration in immune function in the aging orbitofrontal cortex of subjects with MDD. |
Relationships reported by
Miguel-Hidalgo, 2011
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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Suicide (suicide)
|
symptoms |
Intercellular adhesion molecule 1 (intercellular adhesion molecule-1 (ICAM-1)) |
protein |
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Non-psychiatric comparison subjects older than 60 experienced dramatic increase in extravascular ICAM-1 immunoreactivity, but this increase was attenuated in elderly subjects with MDD, particularly in those dying by suicide. |
Positive
|
|
MDD
|
syndrome |
Intercellular adhesion molecule 1 (intercellular adhesion molecule-1 (ICAM-1)) |
protein |
|
Vascular and extravascular fractions of ICAM-1 immunoreactivity were lower in subjects with MDD than in non-psychiatric comparison subjects. |
Positive
|
