Gene Report

Basic Information

Approved Symbol	PUM1
Approved Name	pumilio homolog 1 (Drosophila)
Previous Name	pumilio (Drosophila) homolog 1
Symbol Alias	PUMH1, KIAA0099
Location	1p35.2
Position	chr1:31404353-31538564 (-)
External Links	Entrez Gene: 9698 Ensembl: ENSG00000134644 UCSC: uc001bsh.1 HGNC ID: 14957
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PUM1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PUM1	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.001, F=11.1; Substance: P-value=0.009, F=8.8	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationships between PUM1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
PUM1		Suicide(suicide)	symptoms	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.001, F=11.1; Substance: P-value=0.009, F=8.8	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationship network of PUM1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PUM1 and MDD (count: 0)

Negative relationships between PUM1 and other components at different levels (count: 0)

PUM1 related SNPs in MK4MDD (count: 0)

PUM1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Pumilio homolog 1	Q14671	0(0/0)	Gene mapped

PUM1 related GO terms (count: 5)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016044	cellular membrane organization	biological process	TAS
GO:0006417	regulation of translation	biological process	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0006892	post-Golgi vesicle-mediated transport	biological process	TAS
GO:0003723	RNA binding	molecular function	IEA

PUM1 related KEGG pathways (count: 0)

PUM1 related BioCarta pathways (count: 0)

PUM1 related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19187	clathrin derived_vesicle_budding	There at least two classes of clathrin coated vesicles in ce...... There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat. More...
REACT_19400	golgi associated_vesicle_biogenesis	Proteins that have been synthesized, processed and sorted ev...... Proteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins transported in the vesicle membranes. More...
REACT_11123	membrane trafficking	The secretory membrane system allows a cell to regulate deli...... The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport between themselves and the cell surface. Membrane traffic within this system flows along highly organized directional routes. Secretory cargo is synthesized and assembled in the ER and then transported to the Golgi complex for further processing and maturation. Upon arrival at the trans Golgi network (TGN), the cargo is sorted and packaged into post-Golgi carriers that move through the cytoplasm to fuse with the cell surface. This directional membrane flow is balanced by retrieval pathways that bring membrane and selected proteins back to the compartment of origin. More...

PUM1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PUM1	SMAD1	No	yeast 2-hybrid	15231748
PUM1	ATXN1	No	yeast 2-hybrid	16713569

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways