Gene Report

Basic Information

Approved Symbol	PIK3C2A
Approved Name	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Previous Name	"phosphoinositide-3-kinase, class 2, alpha polypeptide"
Symbol Alias	PI3K-C2alpha
Location	11p15.5-p14
Position	chr11:17229395-17229495 (-)
External Links	Entrez Gene: 5286 Ensembl: ENSG00000011405 UCSC: uc001mmq.4 HGNC ID: 8971
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between PIK3C2A and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PIK3C2A	Tomita H, 2013	patients and normal controls		GPLS genes significantly dysregulated in anterior cingulate ...... GPLS genes significantly dysregulated in anterior cingulate cortex by microarray More...

Positive relationships between PIK3C2A and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
phosphoinositide-3-kinase (class 2 alpha, PIK3C2A)		Suicide(suicide attempt)	symptoms	Lalovic, 2010	patients and normal controls		Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp...... Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects More...

Positive relationship network of PIK3C2A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PIK3C2A and MDD (count: 0)

Negative relationships between PIK3C2A and other components at different levels (count: 0)

PIK3C2A related SNPs in MK4MDD (count: 0)

PIK3C2A related proteins in MK4MDD (count: 0)

PIK3C2A related GO terms (count: 31)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0030136	clathrin-coated vesicle	cellular component	IEA
GO:0046854	phosphatidylinositol phosphorylation	biological process	IEA
GO:0008286	insulin receptor signaling pathway	biological process	TAS[17371240]
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS[17371240]
GO:0005886	plasma membrane	cellular component	IDA[21081650]
GO:0005524	ATP binding	molecular function	IEA
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	biological process	IEA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0005737	cytoplasm	cellular component	IDA[21081650]
GO:0006644	phospholipid metabolic process	biological process	TAS
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0006887	exocytosis	biological process	TAS[17371240]
GO:0016303	1-phosphatidylinositol-3-kinase activity	molecular function	IEA
GO:0005794	Golgi apparatus	cellular component	IEA
GO:0005634	nucleus	cellular component	IEA
GO:0035004	phosphatidylinositol 3-kinase activity	molecular function	TAS[17371240]
GO:0005942	phosphatidylinositol 3-kinase complex	cellular component	IBA
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular function	IBA; TAS
GO:0005829	cytosol	cellular component	TAS
GO:0048268	clathrin coat assembly	biological process	TAS[17371240]
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0031982	vesicle	cellular component	IDA[21081650]
GO:0071583	negative regulation of zinc ion transmembrane transport	biological process	IEA
GO:0006661	phosphatidylinositol biosynthetic process	biological process	TAS
GO:0035091	phosphatidylinositol binding	molecular function	IEA
GO:0016477	cell migration	biological process	IBA
GO:0014829	vascular smooth muscle contraction	biological process	TAS[17371240]
GO:0014065	phosphatidylinositol 3-kinase signaling	biological process	IBA
GO:0048008	platelet-derived growth factor receptor signaling pathway	biological process	TAS[17371240]
GO:0006897	endocytosis	biological process	IMP[21081650]
GO:0070062	extracellular exosome	cellular component	IDA[19056867]

PIK3C2A related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04070	phosphatidylinositol signaling_system	Phosphatidylinositol signaling system

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa00562	inositol phosphate_metabolism	Inositol phosphate metabolism

PIK3C2A related BioCarta pathways (count: 0)

PIK3C2A related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_11123	membrane trafficking	The secretory membrane system allows a cell to regulate deli...... The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport between themselves and the cell surface. Membrane traffic within this system flows along highly organized directional routes. Secretory cargo is synthesized and assembled in the ER and then transported to the Golgi complex for further processing and maturation. Upon arrival at the trans Golgi network (TGN), the cargo is sorted and packaged into post-Golgi carriers that move through the cytoplasm to fuse with the cell surface. This directional membrane flow is balanced by retrieval pathways that bring membrane and selected proteins back to the compartment of origin. More...
REACT_19187	clathrin derived_vesicle_budding	There at least two classes of clathrin coated vesicles in ce...... There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat. More...
REACT_19400	golgi associated_vesicle_biogenesis	Proteins that have been synthesized, processed and sorted ev...... Proteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins transported in the vesicle membranes. More...

PIK3C2A related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PIK3C2A	EGFR	No	in vivo	10805725
PIK3C2A	ERBB2	No	in vivo	10805725

Gene Report

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways

Gene mapped Reactome pathways