Gene Report

Basic Information

Approved Symbol	HADHA
Approved Name	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
Previous Name	"hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit"
Symbol Alias	GBP, LCEH, LCHAD, MTPA
Name Alias	"gastrin-binding protein", "long-chain-3-hydroxyacyl-CoA dehydrogenase", "long-chain 2-enoyl-CoA hydratase", "mitochondrial trifunctional protein, alpha subunit"
Location	2p23
Position	chr2:26467465-26467594 (-)
External Links	Entrez Gene: 3030 Ensembl: ENSG00000084754 UCSC: uc002rgy.3 HGNC ID: 4801
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between HADHA and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
HADHA	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.001, F=11.6; Substance: P-value=0.006, F=10.4	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationships between HADHA and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
HADHA		Suicide(suicide)	symptoms	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.001, F=11.6; Substance: P-value=0.006, F=10.4	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationship network of HADHA in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HADHA and MDD (count: 0)

Negative relationships between HADHA and other components at different levels (count: 0)

HADHA related SNPs in MK4MDD (count: 0)

HADHA related proteins in MK4MDD (count: 0)

HADHA related GO terms (count: 21)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005515	protein binding	molecular function	IPI[20562859]
GO:0044255	cellular lipid metabolic process	biological process	TAS
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0006635	fatty acid beta-oxidation	biological process	IEA; TAS
GO:0046474	glycerophospholipid biosynthetic process	biological process	TAS
GO:0004300	enoyl-CoA hydratase activity	molecular function	IEA
GO:0016508	long-chain-enoyl-CoA hydratase activity	molecular function	IEA
GO:0000062	fatty-acyl-CoA binding	molecular function	IEA
GO:0032403	protein complex binding	molecular function	IEA
GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex	cellular component	IEA
GO:0032868	response to insulin	biological process	IEA
GO:0035965	cardiolipin acyl-chain remodeling	biological process	TAS
GO:0006644	phospholipid metabolic process	biological process	TAS
GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity	molecular function	IEA
GO:0051287	NAD binding	molecular function	IEA
GO:0042493	response to drug	biological process	IEA
GO:0005743	mitochondrial inner membrane	cellular component	TAS
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	molecular function	TAS[8135828]
GO:0005739	mitochondrion	cellular component	IDA[20833797]
GO:0042645	mitochondrial nucleoid	cellular component	IDA[18063578]
GO:0003985	acetyl-CoA C-acetyltransferase activity	molecular function	TAS[8135828]

HADHA related KEGG pathways (count: 9)

ID	Name	Brief Description
Gene mapped KEGG pathways
hsa00410	beta alanine_metabolism	beta-Alanine metabolism
hsa01040	biosynthesis of_unsaturated_fatty_acids	Biosynthesis of unsaturated fatty acids
hsa00650	butanoate metabolism	Butanoate metabolism
hsa00380	tryptophan metabolism	Tryptophan metabolism
hsa00071	fatty acid_metabolism	Fatty acid metabolism
hsa00310	lysine degradation	Lysine degradation
hsa00280	valine leucine_and_isoleucine_degradation	Valine, leucine and isoleucine degradation
hsa00903	limonene and_pinene_degradation	Limonene and pinene degradation
hsa00640	propanoate metabolism	Propanoate metabolism

HADHA related BioCarta pathways (count: 0)

HADHA related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_1473	mitochondrial fatty_acid_beta_oxidation	Beta-oxidation begins once fatty acids have been imported in...... Beta-oxidation begins once fatty acids have been imported into the mitochondrial matrix by carnitine acyltransferases. The beta-oxidation spiral of fatty acids metabolism involves the repetitive removal of two carbon units from the fatty acyl chain. There are four steps to this process: oxidation, hydration, a second oxidation, and finally thiolysis. The last step releases the two-carbon acetyl-CoA and a ready primed acyl-CoA that takes another turn down the spiral. In total each turn of the beta-oxidation spiral produces one NADH, one FADH2, and one acetyl-CoA. Further oxidation of acetyl-CoA via the tricarboxylic acid cycle generates additional FADH2 and NADH. All reduced cofactors are used by the mitochondrial electron transport chain to form ATP. The complete oxidation of a fatty acid molecule produces numerous ATP molecules. Palmitate, used as the model here, produces 129 ATPs. Beta-oxidation pathways differ for saturated and unsaturated fatty acids. The beta-oxidation of saturated fatty acids requires four different enzymatic steps. Beta-oxidation produces and consumes intermediates with a trans configuration; unsaturated fatty acids that have bonds in the cis configuration require three separate enzymatic steps to prepare these molecules for the beta-oxidation pathway. More...
REACT_602	metabolism of_lipids_and_lipoproteins	Lipids are hydrophobic but otherwise chemically diverse mole...... Lipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphingolipids, eicosanoids, cholesterol, bile salts, steroid hormones, and fat-soluble vitamins, and function as a major source of energy (fatty acids, triacylglycerols, and ketone bodies), are major constituents of cell membranes (cholesterol and phospholipids), play a major role in their own digestion and uptake (bile salts), and participate in numerous signaling and regulatory processes (steroid hormones, eicosanoids, and sphingolipids). Because of their poor solubility in water, most lipids in extracellular spaces in the human body are found as complexes with specific carrier proteins. Regulation of the formation and movement of these lipoprotein complexes is a critical aspect of human lipid metabolism, and lipoprotein abnormalities are associated with major human disease processes including atherosclerosis and diabetes. Aspects of lipid metabolism currently annotated in Reactome include lipid digestion, trafficking of dietary sterols, triacylglycerol synthesis (fatty acid synthesis and triacylglycerol assembly), hormone-sensitive lipase-mediated triacylglycerol breakdown, and beta-oxidation of fatty acids, ketone body metabolism (synthesis and utilization), the synthesis of cholesterol, bile salts, and steroid hormones, and sphingolipid metabolism. Three aspects of lipoprotein function are currently annotated: chylomicron-mediated lipid transport, HDL (high density lipoprotein)-mediated lipid transport, and LDL (low density lipoprotein) endocytosis and degradation. More...

HADHA related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways