Study Report
Reference
| Citation | Iosifescu, 2008 PubMed |
| Full Info | Iosifescu, D.V., Greenwald, S., Devlin, P., Perlis, R.H., Denninger, J.W., Alpert, J.E. and Fava, M. (2008) Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder. Acta Psychiatr Scand, 117, 271-276.
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Study
| Hypothesis or Background |
We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD).
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| Sample Information | eighty-two subjects meeting DSM-IV criteria for MDD |
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| Method Detail | Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. |
| Method Keywords | electroencephalogram (EEG) |
| Result | During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. |
| Conclusions | Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD. |
Relationships reported by
Iosifescu, 2008
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Suicide (suicidal ideation (SI))
|
symptoms |
Alpha wave (alpha) |
neurobiological system |
|
Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD. |
Positive
|
|
Suicide (suicidal ideation (SI))
|
symptoms |
Theta wave (theta) |
neurobiological system |
|
Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD. |
Positive
|
