MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Hwang, 2010 PubMed
Full Info	Hwang, J.P., Lee, T.W., Tsai, S.J., Chen, T.J., Yang, C.H., Lirng, J.F. and Tsai, C.F. (2010) Cortical and subcortical abnormalities in late-onset depression with history of suicide attempts investigated with MRI and voxel-based morphometry. J Geriatr Psychiatry Neurol, 23, 171-184.

Study

Hypothesis or Background	Late-onset major depression is thought to have a biological (vascular) basis, which could be a result of brain structure change. Vascular lesions can affect both the gray matter (GM) and white matter (WM), while most previous studies addressed WM abnormality. This study explored the disease- and symptom (history of suicide attempt) -related GM morphometry in elderly male patients with late-onset depression.
Sample Information	A total of 70 patients with depression admitted to our geriatric psychiatric ward were investigated, and 26 age-matched males were recruited as controls.
Method Detail	We used T1-weighted magnetic resonance imaging (MRI) to obtain cerebral structural information and adopted voxel-based morphometry (VBM) to investigate brain volume change related to disease (depression vs control) and symptom (depression with history of suicide attempt vs depression without history of suicide attempt).
Method Keywords	magnetic resonance imaging (MRI)
Result	Late-onset depression was associated with smaller volumes in several regions of GM (insula and the posterior cingulate region) and WM (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum). Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM and WM volume in the frontal, parietal, and temporal regions, and the insula, lentiform nucleus, midbrain, and the cerebellum. Marked regional volume reduction was noticed at dorsal medial prefrontal cortex.
Conclusions	Our results demonstrate that the development of suicidal behaviors in major depression is related to widespread but discrete volume reduction in several cortical and subcortical structures, fitting with the hypothesis that decreased cerebral volume in certain regions renders biological susceptibility to attempt suicide during depressive states.

Relationships reported by Hwang, 2010

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
MDD	syndrome	parahippocampal region (parahippocampal region)	brain morphology and function		Late-onset depression was associated with smaller volumes in several regions of white matter (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum).	Positive
MDD	syndrome	Insula (insula)	brain morphology and function		Late-onset depression was associated with smaller volumes in several regions of gray matter (insula and the posterior cingulate region) and white matter (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum).	Positive
MDD	syndrome	subcallosal cingulate cortex (subcallosal cingulate cortex)	brain morphology and function		Late-onset depression was associated with smaller volumes in several regions of white matter (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum).	Positive
MDD	syndrome	posterior cingulate region (posterior cingulate region)	brain morphology and function		Late-onset depression was associated with smaller volumes in several regions of gray matter (insula and the posterior cingulate region)	Positive
MDD	syndrome	Cerebellum (cerebellum)	brain morphology and function		Late-onset depression was associated with smaller volumes in several regions of white matter (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum).	Positive
MDD	syndrome	Grey matter (gray matter)	brain morphology and function		Late-onset depression was associated with smaller volumes in several regions of gray matter (insula and the posterior cingulate region)	Positive
MDD	syndrome	Lateral ventricles (floor of lateral ventricles)	brain morphology and function		Late-onset depression was associated with smaller volumes in several regions of white matter (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum).	Positive
Suicide (suicide)	symptoms	Lentiform nucleus (lentiform nucleus)	brain morphology and function		Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the lentiform nucleus	Positive
Suicide (suicide)	symptoms	Midbrain (midbrain)	brain morphology and function		Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the midbrain	Positive
Suicide (suicide)	symptoms	Parietal Lobe (parietal regions)	brain morphology and function		Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the parietal regions	Positive
Suicide (suicide)	symptoms	Temporal Lobe (temporal regions)	brain morphology and function		Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the temporal regions	Positive
MDD	syndrome	White matter (white matter)	brain morphology and function		Late-onset depression was associated with smaller volumes in several regions of white matter (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum).	Positive
Suicide (suicide)	symptoms	Cerebellum (cerebellum)	brain morphology and function		Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the cerebellum.	Positive
Suicide (suicide)	symptoms	Frontal Lobe (frontal regions)	brain morphology and function		Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the frontal regions	Positive
Suicide (suicide)	symptoms	Insula (insula)	brain morphology and function		Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the insula	Positive