Brain Morphology and Function Report

Name	Cerebellum
Brain Morphology	The cerebellum is located at the bottom of the brain, with the large mass of the cerebral cortex above it and the portion of the brainstem called the pons in front of it. It is separated from the overlying cerebrum by a layer of leathery dura mater; all of its connections with other parts of the brain travel through the pons.
Brain Function	Cerebellum is associated with regulation and coordination of movement, posture, and balance.
Picture	Source
No. of Studies (Positive/Negative)	21(21/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
cerebellum	Costafreda, 2009	patients and normal controls		Decreased grey matter density in the cerebellum showed the h...... Decreased grey matter density in the cerebellum showed the highest contribution to the diagnosis of depression. More...
cerebellum	D'Haenen H, 1994	patients and normal controls	Mann-Whitney U test P-value = 0.025; The mean basal ganglia/cerebellum uptake ratio was 1.94 (SD = 0.27) in the depressed patients versus 1.74 (SD = 0.17) in the controls.	The basal ganglia/cerebellum 123I-iodobenzamide (a high-affi...... The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. More...
cerebellum	Videbech, 2001	patients and normal controls		The patients had increased activity of the cerebellum compar...... The patients had increased activity of the cerebellum compared to the healthy controls when corrected for these confounders and the influence of antidepressant medication. More...
cerebellum	Kimbrell, 2002	patients and normal controls		Compared with control subjects, the subgroup of patients wit...... Compared with control subjects, the subgroup of patients with Hamilton depression scores of 22 or greater exhibited increased normalized metabolic activity bilaterally in the cerebellum More...
cerebellum	Videbech, 2002	patients and normal controls		The patients had increased blood flow to cerebellum The patients had increased blood flow to cerebellum
cerebellum	Smith, 2002	patients and normal controls		relative to healthy controls, subjects recovered from depres...... relative to healthy controls, subjects recovered from depression showed a reduced response in the cerebellum during anticipation of the noxious stimulus compared with anticipation of the non-noxious stimulus. More...
cerebellum	Agid, 2003	patients and normal controls	P-value = 0.004	Mean volume of T2-WIH was significantly greater (p=0.004) in...... Mean volume of T2-WIH was significantly greater (p=0.004) in depressed subjects. In the control group T2-WIH(T2-weighted image 'hyperintensities') were exclusively located in the supratentorial hemispheral white matter while in the depressed group T2-WIH were also found in basal ganglia, temporal lobe, cerebellum and brainstem. More...
cerebellum	Holthoff, 2004	patients only		There were significant decreases in metabolism upon remissio...... There were significant decreases in metabolism upon remission with respect to the baseline scan in left prefrontal, anterior temporal and anterior cingulate cortex and bilateral thalamus (SPM analysis) and bilateral putamen and cerebellum (SPM and ROI analyses). More...
cerebellum	Canli, 2004	patients and normal controls		For happy words, depressed subjects exhibited less activatio...... For happy words, depressed subjects exhibited less activation than did controls to happy words in fronto-temporal and limbic regions. For sad words, depressed subjects showed more activation than did controls in the inferior parietal lobule and less activation in the superior temporal gyrus and cerebellum More...
cerebellum	Nofzinger, 2005	patients and normal controls		Depressed patients showed larger decreases than healthy subj...... Depressed patients showed larger decreases than healthy subjects in relative metabolism in the cerebellum More...
cerebellum	Fujimoto, 2008	patients only		The 3D-SSP score map showed increased relative metabolism in...... The 3D-SSP score map showed increased relative metabolism in the cerebellum in both hemispheres in patients compared with controls. More...
cerebellum	Vasic, 2009	patients and normal controls		Within this cortical network, MDD patients additionally reve...... Within this cortical network, MDD patients additionally revealed a pattern of increased functional connectivity in the left DLPFC and the cerebellum compared to healthy controls. More...
cerebellum	Frodl, 2010	patients and normal controls		Dorsal anterior cingulate cortex, precuneus, and cerebellum ...... Dorsal anterior cingulate cortex, precuneus, and cerebellum activity showed less connectivity with the OFC in patients than in control subjects More...
cerebellum	Abe, 2010	patients and normal controls		Local areas showing an increase of MD (mean diffusivity) in ...... Local areas showing an increase of MD (mean diffusivity) in depressive patients were observed in the cerebellum More...
cerebellum	Naismith, 2010	patients and normal controls		control subjects showed significantly greater activity in th...... control subjects showed significantly greater activity in the middle frontal gyrus whereas the patients exhibited greater activity in the cerebellum. More...
cerebellum	Hwang, 2010	patients and normal controls		Late-onset depression was associated with smaller volumes in...... Late-onset depression was associated with smaller volumes in several regions of white matter (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum). More...
cerebellar gray matter (CGM)	Parsey, 2010	patients and normal controls	P-value = .007	CGM V(T) (volume of distribution) was higher in NRM (not rec...... CGM V(T) (volume of distribution) was higher in NRM (not recently medicated MDD subjects) compared with control subjects (p = .007). More...
cerebellum	Scheuerecker, 2010	patients and normal controls		As shown by voxel-based morphometry, depressed patients had ...... As shown by voxel-based morphometry, depressed patients had reductions in orbitofrontal cortex volume and increases in cerebellar volume. More...
bilateral cerebellums	Lai, 2010	patients and normal controls		Patients had deficits of gray matter volumes over bilateral ...... Patients had deficits of gray matter volumes over bilateral cerebellums when compared to controls. More...
cerebellum	Lee, 2011	patients and normal controls		Decreased gray matter concentration (GMC) was found in MDD p...... Decreased gray matter concentration (GMC) was found in MDD patients in the central lobule of the cerebellum, and the midbrain encompassing the dorsal raphe nuclei (DRN). More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
cerebellum		D(2) dopamine receptor(dopamine D2 receptor)	protein	D'Haenen H, 1994	patients and normal controls		The basal ganglia/cerebellum 123I-iodobenzamide (a high-affi...... The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. More...
cerebellum		Dorsolateral prefrontal cortex(dorsolateral prefrontal cortex (DLPFC))	brain morphology and function	Vasic, 2009	patients and normal controls		Within this cortical network, MDD patients additionally reve...... Within this cortical network, MDD patients additionally revealed a pattern of increased functional connectivity in the left DLPFC and the cerebellum compared to healthy controls. More...
cerebellum		Orbitofrontal cortex(orbitofrontal cortex)	brain morphology and function	Frodl, 2010	patients and normal controls		Dorsal anterior cingulate cortex, precuneus, and cerebellum ...... Dorsal anterior cingulate cortex, precuneus, and cerebellum activity showed less connectivity with the OFC in patients than in control subjects More...
cerebellum		Orbitofrontal cortex(orbitofrontal cortex (OFC))	brain morphology and function	Frodl, 2010	patients and normal controls		Cerebellum activity showed less connectivity with the orbito...... Cerebellum activity showed less connectivity with the orbitofrontal cortex (OFC) in patients than in control subjects. More...
cerebellum		Depressed mood(depressed mood)	symptoms	Fu, 2004	patients and normal controls		Reduction of depressive symptoms in the patient group was as...... Reduction of depressive symptoms in the patient group was associated with reduction of dynamic range in the cerebellum. More...
cerebellum		Suicide(suicide)	symptoms	Hwang, 2010	patients and normal controls		Compared with nonsuicidal counterpart, suicidal depression w...... Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the cerebellum. More...

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Note:
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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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