MK4MDD

Brain Morphology and Function Report

Basic Information
Name Cerebellum
Brain Morphology "The cerebellum is located at the bottom of the brain, with the large mass of the cerebral cortex above it and the portion of the brainstem called the pons in front of it. It is separated from the overlying cerebrum by a layer of leathery dura mater; all of its connections with other parts of the brain travel through the pons."
Brain Function "Cerebellum is associated with regulation and coordination of movement, posture, and balance."
Picture Cerebellum Source Magnify
No. of Studies (Positive/Negative) 22(22/0) Help

Positive relationships between Cerebellum and MDD (count: 20)
Name in Literature Reference Research Type Statistical Result Relation Description Help
cerebellum Costafreda, 2009 patients and normal controls Decreased grey matter density in the cerebellum showed the h...... Decreased grey matter density in the cerebellum showed the highest contribution to the diagnosis of depression. More...
cerebellum D'Haenen H, 1994 patients and normal controls Mann-Whitney U test P-value = 0.025; The mean basal ganglia/cerebellum uptake ratio was 1.94 (SD = 0.27) in the depressed patients versus 1.74 (SD = 0.17) in the controls. The basal ganglia/cerebellum 123I-iodobenzamide (a high-affi...... The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. More...
cerebellum Videbech, 2001 patients and normal controls The patients had increased activity of the cerebellum compar...... The patients had increased activity of the cerebellum compared to the healthy controls when corrected for these confounders and the influence of antidepressant medication. More...
cerebellum Kimbrell, 2002 patients and normal controls Compared with control subjects, the subgroup of patients wit...... Compared with control subjects, the subgroup of patients with Hamilton depression scores of 22 or greater exhibited increased normalized metabolic activity bilaterally in the cerebellum More...
cerebellum Videbech, 2002 patients and normal controls The patients had increased blood flow to cerebellum The patients had increased blood flow to cerebellum
cerebellum Smith, 2002 patients and normal controls relative to healthy controls, subjects recovered from depres...... relative to healthy controls, subjects recovered from depression showed a reduced response in the cerebellum during anticipation of the noxious stimulus compared with anticipation of the non-noxious stimulus. More...
cerebellum Agid, 2003 patients and normal controls P-value = 0.004 Mean volume of T2-WIH was significantly greater (p=0.004) in...... Mean volume of T2-WIH was significantly greater (p=0.004) in depressed subjects. In the control group T2-WIH(T2-weighted image 'hyperintensities') were exclusively located in the supratentorial hemispheral white matter while in the depressed group T2-WIH were also found in basal ganglia, temporal lobe, cerebellum and brainstem. More...
cerebellum Holthoff, 2004 patients only There were significant decreases in metabolism upon remissio...... There were significant decreases in metabolism upon remission with respect to the baseline scan in left prefrontal, anterior temporal and anterior cingulate cortex and bilateral thalamus (SPM analysis) and bilateral putamen and cerebellum (SPM and ROI analyses). More...
cerebellum Canli, 2004 patients and normal controls For happy words, depressed subjects exhibited less activatio...... For happy words, depressed subjects exhibited less activation than did controls to happy words in fronto-temporal and limbic regions. For sad words, depressed subjects showed more activation than did controls in the inferior parietal lobule and less activation in the superior temporal gyrus and cerebellum More...
cerebellum Nofzinger, 2005 patients and normal controls Depressed patients showed larger decreases than healthy subj...... Depressed patients showed larger decreases than healthy subjects in relative metabolism in the cerebellum More...
cerebellum Fujimoto, 2008 patients only The 3D-SSP score map showed increased relative metabolism in...... The 3D-SSP score map showed increased relative metabolism in the cerebellum in both hemispheres in patients compared with controls. More...
cerebellum Vasic, 2009 patients and normal controls Within this cortical network, MDD patients additionally reve...... Within this cortical network, MDD patients additionally revealed a pattern of increased functional connectivity in the left DLPFC and the cerebellum compared to healthy controls. More...
cerebellum Frodl, 2010 patients and normal controls Dorsal anterior cingulate cortex, precuneus, and cerebellum ...... Dorsal anterior cingulate cortex, precuneus, and cerebellum activity showed less connectivity with the OFC in patients than in control subjects More...
cerebellum Abe, 2010 patients and normal controls Local areas showing an increase of MD (mean diffusivity) in ...... Local areas showing an increase of MD (mean diffusivity) in depressive patients were observed in the cerebellum More...
cerebellum Naismith, 2010 patients and normal controls control subjects showed significantly greater activity in th...... control subjects showed significantly greater activity in the middle frontal gyrus whereas the patients exhibited greater activity in the cerebellum. More...
cerebellum Hwang, 2010 patients and normal controls Late-onset depression was associated with smaller volumes in...... Late-onset depression was associated with smaller volumes in several regions of white matter (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum). More...
cerebellar gray matter (CGM) Parsey, 2010 patients and normal controls P-value = .007 CGM V(T) (volume of distribution) was higher in NRM (not rec...... CGM V(T) (volume of distribution) was higher in NRM (not recently medicated MDD subjects) compared with control subjects (p = .007). More...
cerebellum Scheuerecker, 2010 patients and normal controls As shown by voxel-based morphometry, depressed patients had ...... As shown by voxel-based morphometry, depressed patients had reductions in orbitofrontal cortex volume and increases in cerebellar volume. More...
bilateral cerebellums Lai, 2010 patients and normal controls Patients had deficits of gray matter volumes over bilateral ...... Patients had deficits of gray matter volumes over bilateral cerebellums when compared to controls. More...
cerebellum Lee, 2011 patients and normal controls Decreased gray matter concentration (GMC) was found in MDD p...... Decreased gray matter concentration (GMC) was found in MDD patients in the central lobule of the cerebellum, and the midbrain encompassing the dorsal raphe nuclei (DRN). More...

Positive relationships between Cerebellum and other components at different levels (count: 7) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Cerebellum in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Cerebellum and MDD (count: 0)
Negative relationships between Cerebellum and other components at different levels (count: 0) Help