Study Report
Reference
| Citation | D'Haenen H, 1994 PubMed |
| Full Info | D'Haenen H, A. and Bossuyt, A. (1994) Dopamine D2 receptors in depression measured with single photon emission computed tomography. Biol Psychiatry, 35, 128-132.
|
Study
| Hypothesis or Background |
Psychobiological theories of mood disorders have been concerned mainly with noradrenaline and serotonin. There exists, however, a recent upsurge of interest in dopamine.
|
| Sample Information | Subjects were 21 (unipolar) depressed inpatients and 11 normal controls. Patients were absence of antidepressant medications for at least 7 days. |
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| Method Detail | We have used single photon emission computed tomography and 123I-iodobenzamide, a high-affinity ligand for D2 receptors, to study these receptors in depression. |
| Method Keywords | single photon emission computed tomography (SPECT); psychometric method |
| Result | The mean basal ganglia/cerebellum uptake ratio was 1.94 (+/- 0.27) in the depressed patients versus 1.74 (+/- 0.17) in the controls. This difference was statistically significant (Mann-Whitney U test, p = 0.025). |
| Conclusions | These data could indicate an increase of D2 receptor density in depression. |
Relationships reported by
D'Haenen H, 1994
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Basal ganglia (basal ganglia) |
brain morphology and function |
Mann-Whitney U test P-value = 0.025; The mean basal ganglia/cerebellum uptake ratio was 1.94 (SD= 0.27) in the depressed patients versus 1.74 (SD= 0.17) in the controls. |
The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. |
Positive
|
|
MDD
|
syndrome |
Cerebellum (cerebellum) |
brain morphology and function |
Mann-Whitney U test P-value = 0.025; The mean basal ganglia/cerebellum uptake ratio was 1.94 (SD = 0.27) in the depressed patients versus 1.74 (SD = 0.17) in the controls. |
The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. |
Positive
|
|
Basal ganglia (basal ganglia)
|
brain morphology and function |
D(2) dopamine receptor (dopamine D2 receptor) |
protein |
|
The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. |
Positive
|
|
Cerebellum (cerebellum)
|
brain morphology and function |
D(2) dopamine receptor (dopamine D2 receptor) |
protein |
|
The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. |
Positive
|
|
MDD
|
syndrome |
D(2) dopamine receptor (dopamine D2 receptor) |
protein |
|
The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. |
Positive
|
