MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Abe, 2010 PubMed
Full Info	Abe, O., Yamasue, H., Kasai, K., Yamada, H., Aoki, S., Inoue, H., Takei, K., Suga, M., Matsuo, K., Kato, T. et al. (2010) Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression. Psychiatry Res, 181, 64-70.

Study

Hypothesis or Background
Sample Information	21 right-handed patients and 42 age- and gender-matched right-handed normal subjects
Method Detail	The purpose of this study is to use voxel-based analysis to simultaneously elucidate regional changes in gray/white matter volume, mean diffusivity (MD), and fractional anisotropy (FA) in patients with unipolar major depressive disorder.
Method Keywords	diffusion tensor imaging (DTI)
Result	Local areas showing significant gray matter volume reduction in depressive patients compared with controls were observed in the right parahippocampal gyrus, hippocampus, bilateral middle frontal gyri, bilateral anterior cingulate cortices, left parietal and occipital lobes, and right superior temporal gyrus. Local areas showing an increase of MD in depressive patients were observed in the bilateral parahippocampal gyri, hippocampus, pons, cerebellum, left frontal and temporal lobes, and right frontal lobe. There was no significant difference between the two groups for FA and white matter volume in the entire brain. Although there was no local area where brain volume and MD were significantly correlated with disease severity, FA tended to correlate negatively with total days depressed in the right anterior cingulate and the left frontal white matter.
Conclusions	These results suggest that the frontolimbic neural circuit might play an important role in the neuropathology of patients with major depressive disorder.

Relationships reported by Abe, 2010

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
MDD	syndrome	Cerebellum (cerebellum)	brain morphology and function		Local areas showing an increase of MD (mean diffusivity) in depressive patients were observed in the cerebellum	Positive
MDD	syndrome	Hippocampus (hippocampus)	brain morphology and function		Local areas showing significant gray matter volume reduction in depressive patients compared with controls were observed in the hippocampus. Local areas showing an increase of MD (mean diffusivity) in depressive patients were observed in the hippocampus.	Positive
MDD	syndrome	Anterior cingulate cortex (anterior cingulate cortices)	brain morphology and function		Local areas showing significant gray matter volume reduction in depressive patients compared with controls were observed in the bilateral anterior cingulate cortices	Positive
MDD	syndrome	parahippocampal region (bilateral parahippocampal gyri)	brain morphology and function		Local areas showing an increase of MD (mean diffusivity) in depressive patients were observed in the bilateral parahippocampal gyri	Positive
MDD	syndrome	Temporal Lobe (temporal lobe)	brain morphology and function		Local areas showing an increase of MD (mean diffusivity) in depressive patients were observed in the temporal lobe	Positive
MDD	syndrome	Parietal Lobe (parietal lobe)	brain morphology and function		Local areas showing significant gray matter volume reduction in depressive patients compared with controls were observed in the left parietal lobe	Positive
MDD	syndrome	Occipital Lobe (occipital lobe)	brain morphology and function		Local areas showing significant gray matter volume reduction in depressive patients compared with controls were observed in the occipital lobe	Positive
MDD	syndrome	Middle frontal gyrus (middle frontal gyri)	brain morphology and function		Local areas showing significant gray matter volume reduction in depressive patients compared with controls were observed in the bilateral middle frontal gyri.	Positive
MDD	syndrome	left frontal cortex (left frontal lobe)	brain morphology and function		Local areas showing an increase of MD (mean diffusivity) in depressive patients were observed in the left frontal and temporal lobes	Positive
MDD	syndrome	right superior temporal gyrus (right superior temporal gyrus)	brain morphology and function		Local areas showing significant gray matter volume reduction in depressive patients compared with controls were observed in the right superior temporal gyrus.	Positive
MDD	syndrome	right parahippocampal gyrus (right parahippocampal gyrus)	brain morphology and function		Local areas showing significant gray matter volume reduction in depressive patients compared with controls were observed in the right parahippocampal gyrus.	Positive
MDD	syndrome	right frontal cortex (right frontal lobe)	brain morphology and function		Local areas showing an increase of MD (mean diffusivity) in depressive patients were observed in the right frontal lobe.	Positive
MDD	syndrome	Pons (pons)	brain morphology and function		Local areas showing an increase of MD (mean diffusivity) in depressive patients were observed in the pons	Positive