MK4MDD

Study Report

Reference
CitationVidebech, 2002 PubMed
Full InfoVidebech, P., Ravnkilde, B., Pedersen, T.H., Hartvig, H., Egander, A., Clemmensen, K., Rasmussen, N.A., Andersen, F., Gjedde, A. and Rosenberg, R. (2002) The Danish PET/depression project: clinical symptoms and cerebral blood flow. A regions-of-interest analysis. Acta Psychiatr Scand, 106, 35-44.

Study
Hypothesis or Background We wanted to explore associations between clinical symptoms of depression and the blood flow to specific regions of the brain. Furthermore, we wanted to compare the regions-of-interest (ROI) method with the functions-of-interest (FOI) approach.
Sample Information42 representative in-patients with major depression and 47 matched healthy controls
Method DetailThe resting blood flow to 42 ROI in the brain was obtained with positron emission tomography (PET) imaging in 42 representative in-patients with major depression and 47 matched healthy controls.
Method Keywordspositron emission tomography (PET)
ResultThe patients had increased blood flow to hippocampus, cerebellum, anterior cingulate gyrus, and the basal ganglia. A strong negative correlation was found between the degree of psychomotor retardation of the patients and the blood flow to the dorsolateral and supraorbital prefrontal cortices. The total Hamilton score was correlated with the blood flow to the hippocampus.
ConclusionsOur findings support the notion that depressed patients have disturbances in the loops connecting the frontal lobes, limbic system, basal ganglia, and cerebellum.

Relationships reported by Videbech, 2002