Gene Report

Basic Information

Approved Symbol	LAMP1
Approved Name	lysosomal-associated membrane protein 1
Symbol Alias	CD107a
Location	13q34
Position	chr13:113976737-113977741 (+)
External Links	Entrez Gene: 3916 Ensembl: ENSG00000185896 UCSC: uc001vtm.1 HGNC ID: 6499
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between LAMP1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
LAMP1	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.004, F=7.4; Substance: P-value=0.009, F=8.2	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationships between LAMP1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
LAMP1		Suicide(suicide)	symptoms	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.004, F=7.4; Substance: P-value=0.009, F=8.2	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationship network of LAMP1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between LAMP1 and MDD (count: 0)

Negative relationships between LAMP1 and other components at different levels (count: 0)

LAMP1 related SNPs in MK4MDD (count: 0)

LAMP1 related proteins in MK4MDD (count: 0)

LAMP1 related GO terms (count: 34)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0008021	synaptic vesicle	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005515	protein binding	molecular function	IPI[23394946\|24970085]
GO:0010008	endosome membrane	cellular component	ISS
GO:0090160	Golgi to lysosome transport	biological process	IMP[23632890]
GO:1902513	regulation of organelle transport along microtubule	biological process	IMP[23632890]
GO:0046718	viral entry into host cell	biological process	IEA
GO:0005765	lysosomal membrane	cellular component	ISS
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0043025	neuronal cell body	cellular component	IEA
GO:0005764	lysosome	cellular component	IDA[15052268\|15292400\|15613468\|16542649\|22792322\|23704327]; IDA[15613468]
GO:0009897	external side of plasma membrane	cellular component	IEA
GO:0019899	enzyme binding	molecular function	IPI[22641697]
GO:0006914	autophagy	biological process	IEA
GO:0043323	positive regulation of natural killer cell degranulation	biological process	IMP[23632890]
GO:0044194	cytolytic granule	cellular component	IEA
GO:0048102	autophagic cell death	biological process	IEA
GO:0005771	multivesicular body	cellular component	IEA
GO:0048471	perinuclear region of cytoplasm	cellular component	IMP[18787122]
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|23376485\|23533145]
GO:0097208	alveolar lamellar body	cellular component	IEA
GO:0030425	dendrite	cellular component	IEA
GO:0050821	protein stabilization	biological process	ISS
GO:0005770	late endosome	cellular component	IDA[15052268\|15292400\|15792797\|16542649\|18388320\|18767904]
GO:0005737	cytoplasm	cellular component	IDA[21266579]
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	biological process	IMP[23632890]
GO:0008626	granzyme-mediated apoptotic signaling pathway	biological process	IMP[23632890]
GO:0005886	plasma membrane	cellular component	IDA[20956541]
GO:0061474	phagolysosome membrane	cellular component	IEA
GO:0019904	protein domain specific binding	molecular function	IEA
GO:0001618	virus receptor activity	molecular function	IEA
GO:0005887	integral component of plasma membrane	cellular component	TAS[3174652]
GO:0042383	sarcolemma	cellular component	IEA
GO:0072594	establishment of protein localization to organelle	biological process	IMP[23632890]
GO:0042470	melanosome	cellular component	IEA

LAMP1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04142	lysosome	Lysosome	Lysosomes are membrane-delimited organelles in animal cells ...... Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy. More...

LAMP1 related BioCarta pathways (count: 0)

LAMP1 related Reactome pathways (count: 0)

LAMP1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
LAMP1	AP1M1	No	in vitro;yeast 2-hybrid	7569928
LAMP1	AP2M1	No	in vitro;yeast 2-hybrid	7569928

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways