Gene Report

Basic Information

Approved Symbol	DYNC1LI1
Approved Name	dynein, cytoplasmic 1, light intermediate chain 1
Previous Symbol	DNCLI1
Previous Name	"dynein, cytoplasmic, light intermediate polypeptide 1"
Location	3p23
Position	chr3:32612263-32612366 (-)
External Links	Entrez Gene: 51143 Ensembl: ENSG00000144635 UCSC: uc003cfb.4 HGNC ID: 18745
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between DYNC1LI1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DNCLI1	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.001, F=10.8; Substance: P-value=0.001, F=14.1	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationships between DYNC1LI1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
DNCLI1		Suicide(suicide)	symptoms	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.001, F=10.8; Substance: P-value=0.001, F=14.1	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationship network of DYNC1LI1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DYNC1LI1 and MDD (count: 0)

Negative relationships between DYNC1LI1 and other components at different levels (count: 0)

DYNC1LI1 related SNPs in MK4MDD (count: 0)

DYNC1LI1 related proteins in MK4MDD (count: 0)

DYNC1LI1 related GO terms (count: 25)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0008152	metabolic process	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005874	microtubule	cellular component	IEA
GO:0005525	GTP binding	molecular function	IDA[25272277]
GO:0005886	plasma membrane	cellular component	IDA
GO:0005515	protein binding	molecular function	IPI[25272277\|25416956]
GO:0005813	centrosome	cellular component	IDA[21399614]
GO:0005654	nucleoplasm	cellular component	IDA
GO:0005737	cytoplasm	cellular component	IDA
GO:0007018	microtubule-based movement	biological process	IEA
GO:0019003	GDP binding	molecular function	IDA[25272277]
GO:0006810	transport	biological process	IEA
GO:0045504	dynein heavy chain binding	molecular function	IPI[25272277]
GO:0000777	condensed chromosome kinetochore	cellular component	IEA
GO:0051301	cell division	biological process	IEA
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0016032	viral process	biological process	IEA
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]
GO:0000776	kinetochore	cellular component	IDA[19229290]
GO:0000922	spindle pole	cellular component	IDA[19229290]
GO:0003777	microtubule motor activity	molecular function	IEA
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	biological process	IMP[19229290]
GO:0005868	cytoplasmic dynein complex	cellular component	IDA[19229290\|25272277]
GO:0005524	ATP binding	molecular function	IEA
GO:0007067	mitotic nuclear division	biological process	IEA

DYNC1LI1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04962	vasopressin regulated_water_reabsorption	Vasopressin-regulated water reabsorption	In the kidney, the antidiuretic hormone vasopressin (AVP) is...... In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again. More...

DYNC1LI1 related BioCarta pathways (count: 0)

DYNC1LI1 related Reactome pathways (count: 0)

DYNC1LI1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DYNC1LI1	NUP85	No	in vivo	10893222
DYNC1LI1	RAB4A	No	yeast 2-hybrid	11243854

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways