MK4MDD

Gene Report

Basic Information
Approved Symbol TPH2
Approved Name tryptophan hydroxylase 2
Symbol Alias NTPH, FLJ37295
Location 12q15
Position chr12:72425476-72425575 (+)
External Links Entrez Gene: 121278
Ensembl: ENSG00000139287
UCSC: uc009zrw.1
HGNC ID: 20692
No. of Studies (Positive/Negative) 15(11/4) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between TPH2 and MDD (count: 7)
Name in Literature Reference Research Type Statistical Result Relation Description Help
TPH2 Zill, 2004 patients and normal controls P-value<0.01 Significant association was detected between one SNP (P=0.00...... Significant association was detected between one SNP (P=0.0012, global P=0.0051) and MD. Haplotype analysis produced additional support for association (P<0.0001, global P=0.0001). More...
TPH2 Bach-Mizrachi, 2006 patients and normal controls TPH2 expression is 33% higher in the DRN and 17% higher in t...... TPH2 expression is 33% higher in the DRN and 17% higher in the MRN as compared to matched nonpsychiatric controls More...
TPH2 Zhang, 2007 patients and normal controls P-value<0.001 There were remarkably significant differences in gene types ...... There were remarkably significant differences in gene types and gene frequency between case and control groups (P < 0.001). More...
TPH2 Tsai, 2009 patients and normal controls P-value=0.002 In single-marker-based analysis, the rs17110747-G homozygote...... In single-marker-based analysis, the rs17110747-G homozygote polymorphism in this gene was found to be more frequent in the MDD patients than in the controls (P=0.002) More...
TPH2 Lin, 2009 patients and normal controls P-value<0.05 The TPH2 2755A allele was found only in women with peripartu...... The TPH2 2755A allele was found only in women with peripartum major depression and anxiety disorder (p = 0.043) and exhibited a dominant gene action (p = 0.038) with an estimated disease risk of 1.73. More...
TPH2 Xinhua, 2011 patients and normal controls P-value<0.05 The frequency of the A-A haplotype in TPH2 gene was signific...... The frequency of the A-A haplotype in TPH2 gene was significantly higher in female MDD compared to healthy female controls (P<0.05). More...
TPH2 Zhang, 2015 patients only P-value=0.0005 TPH2 mRNA expression levels differed significantly between 5...... TPH2 mRNA expression levels differed significantly between 50 patients with MDD who had attempted suicide (MDD + suicide group) and 75 control patients with MDD (MDD group); TPH2 expression levels were significantly decreased (P=0.0005) in the patients who had attempted suicide. Furthermore, the frequency of TPH2 methylation was 36.0% in the MDD + suicide group, while it was 13.0% in the MDD group. More...

Positive relationships between TPH2 and other components at different levels (count: 4) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of TPH2 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between TPH2 and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description
TPH-2 Gizatullin R, 2008 Patients and nomal controls Neither single marker nor haplotype-based analyses showed si...... Neither single marker nor haplotype-based analyses showed significant associations between TPH-2 and MD More...
TPH2 Nazree NE, 2013 patients and normal controls Single locus analysis in pooled and ethnically stratified su...... Single locus analysis in pooled and ethnically stratified subjects revealed no association between each of the three variants of the TPH2 gene with susceptibility to MDD More...
TPH2 Hammer C, 2014 Patients and nomal controls P=0.88, Odds ratio (CI)=0.95 (0.53¨C1.73) We did not find significant associations between the microde...... We did not find significant associations between the microdeletion in TPH2 and MDD or BPAD (Table 1). There was no deviation from Hardy¨CWeinberg equilibrium. No duplication of the genomic sequence spanning the microdeletion was found in either the patient or the control sample. More...

Negative relationships between TPH2 and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


TPH2 related SNPs in MK4MDD (count: 2)
TPH2 related proteins in MK4MDD (count: 1)
TPH2 related GO terms (count: 18)
TPH2 related KEGG pathways (count: 1)
TPH2 related BioCarta pathways (count: 0)
TPH2 related Reactome pathways (count: 0)
TPH2 related interactors from protein-protein interaction data in HPRD (count: 0)