Gene Report

Basic Information

Approved Symbol	TPH2
Approved Name	tryptophan hydroxylase 2
Symbol Alias	NTPH, FLJ37295
Location	12q15
Position	chr12:72332626-72426221 (+)
External Links	Entrez Gene: 121278 Ensembl: ENSG00000139287 UCSC: uc009zrw.1 HGNC ID: 20692
No. of Studies (Positive/Negative)	11(10/1)
Type	Literature-origin; SNP mapped; Protein mapped

Positive relationships between TPH2 and MDD (count: 6)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TPH2	Zill, 2004	patients and normal controls	P-value<0.01	Significant association was detected between one SNP (P=0.00...... Significant association was detected between one SNP (P=0.0012, global P=0.0051) and MD. Haplotype analysis produced additional support for association (P<0.0001, global P=0.0001). More...
TPH2	Bach-Mizrachi, 2006	patients and normal controls		TPH2 expression is 33% higher in the DRN and 17% higher in t...... TPH2 expression is 33% higher in the DRN and 17% higher in the MRN as compared to matched nonpsychiatric controls More...
TPH2	Zhang, 2007	patients and normal controls	P-value<0.001	There were remarkably significant differences in gene types ...... There were remarkably significant differences in gene types and gene frequency between case and control groups (P < 0.001). More...
TPH2	Tsai, 2009	patients and normal controls	P-value=0.002	In single-marker-based analysis, the rs17110747-G homozygote...... In single-marker-based analysis, the rs17110747-G homozygote polymorphism in this gene was found to be more frequent in the MDD patients than in the controls (P=0.002) More...
TPH2	Lin, 2009	patients and normal controls	P-value<0.05	The TPH2 2755A allele was found only in women with peripartu...... The TPH2 2755A allele was found only in women with peripartum major depression and anxiety disorder (p = 0.043) and exhibited a dominant gene action (p = 0.038) with an estimated disease risk of 1.73. More...
TPH2	Xinhua, 2011	patients and normal controls	P-value<0.05	The frequency of the A-A haplotype in TPH2 gene was signific...... The frequency of the A-A haplotype in TPH2 gene was significantly higher in female MDD compared to healthy female controls (P<0.05). More...

Positive relationships between TPH2 and other components at different levels (count: 4)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
TPH2		Suicide(suicide)	symptoms	Zhou, 2005	patients and normal controls		The yin haplotype, 212121,(in TPH2 gene) was increased in f...... The yin haplotype, 212121,(in TPH2 gene) was increased in frequency in suicide attempters in both populations tested (Finnish whites and African Americans) More...
TPH2		Suicide(suicide attempt)	symptoms	Lopez de Lara, 2007	patients only		We found two upstream and two intronic SNPs of this gene ass...... We found two upstream and two intronic SNPs of this gene associated with suicide. More...
TPH2		Suicide(suicide attempt)	symptoms	Yoon, 2009	patients only		There were statistically significant differences in the geno...... There were statistically significant differences in the genotype distributions and allele frequencies of TPH2 -703G/T between the suicidal depressive group and the normal control group More...
TPH2		Suicide(suicide attempt)	symptoms	Zhang, 2010	patients only	OR 0.33, 95% CI 0.22-0.99	The multivariate logistic regression analysis indicated that...... The multivariate logistic regression analysis indicated that TPH2 rs7305115 AA (OR 0.33, 95% CI 0.22-0.99), family history of suicide (OR 2.98, 95% CI 1.17-5.04), negative life events half year ago (OR 6.64, 95% CI 2.48-11.04) and hopelessness (OR 7.68, 95% CI 5.79-13.74) were significantly associated with the suicide behaviors in MDD patients. More...

Positive relationship network of TPH2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between TPH2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TPH-2	Gizatullin R, 2008	Patients and nomal controls		Neither single marker nor haplotype-based analyses showed si...... Neither single marker nor haplotype-based analyses showed significant associations between TPH-2 and MD More...

Negative relationships between TPH2 and other components at different levels (count: 0)

TPH2 related SNPs in MK4MDD (count: 5)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs1386486	chr12:72412220(Forward)	intron_variant	1(1/0)
rs1843809	chr12:72348698(Forward)	intron_variant; NMD_transcript_variant	1(1/0)
rs2171363	chr12:72360264(Forward)	downstream_gene_variant; intron_variant	1(1/0)
rs1386494	chr12:72352543(Forward)	intron_variant; NMD_transcript_variant	1(1/0)
rs17110747	chr12:72425954(Forward)	3_prime_UTR_variant; intron_variant; nc_transcript_variant	1(1/0)

TPH2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Tryptophan 5-hydroxylase 2	Q8IWU9	1(1/0)	Literature-origin

TPH2 related GO terms (count: 18)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006950	response to stress	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005829	cytosol	cellular component	TAS
GO:0004510	tryptophan 5-monooxygenase activity	molecular function	IEA
GO:0046219	indolalkylamine biosynthetic process	biological process	TAS
GO:0009072	aromatic amino acid family metabolic process	biological process	IEA
GO:0071285	cellular response to lithium ion	biological process	IEA
GO:0016597	amino acid binding	molecular function	IEA
GO:0014823	response to activity	biological process	IEA
GO:0043627	response to estrogen stimulus	biological process	IEA
GO:0043005	neuron projection	cellular component	IEA
GO:0051384	response to glucocorticoid stimulus	biological process	IEA
GO:0005506	iron ion binding	molecular function	IEA
GO:0042427	serotonin biosynthetic process	biological process	IEA
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS
GO:0031667	response to nutrient levels	biological process	IEA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0007623	circadian rhythm	biological process	IEA
GO:0051592	response to calcium ion	biological process	IEA

TPH2 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00380	tryptophan metabolism	Tryptophan metabolism

TPH2 related BioCarta pathways (count: 0)

TPH2 related Reactome pathways (count: 0)

TPH2 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways