Molecule Report

Basic Information

Name	Methoxyhydroxyphenylglycol
Description	Synthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover.
MeSH ID	D008734
No. of Studies (Positive/Negative)	3(3/0)

Positive relationship between Methoxyhydroxyphenylglycol and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
MHPG	Koenigsberg, 2004	patients and normal controls		The depressed patients had phase advanced circadian rhythms ...... The depressed patients had phase advanced circadian rhythms for cortisol, norepinephrine and MHPG, phase advanced hemicircadian rhythms for cortisol and prolactin, and a phase advanced ultradian rhythm for prolactin compared to healthy control subjects. More...

Positive relationships between Methoxyhydroxyphenylglycol and other components at different levels (count: 2)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
3-methoxy-4-hydroxyphenylglycol (MHPG)		Increased agitation(agitation)	symptoms	Yukimasa, 2006	patients only		The levels of plasma MHPG, but not those of HVA (homovanilli...... The levels of plasma MHPG, but not those of HVA (homovanillic acid), were significantly reduced after rTMS treatment, and a negative correlation was observed between the change in plasma MHPG levels and the change in scores of agitation. More...
3-methoxy-4-hydroxphenylglycol (MHPG)		Suicide(suicide)	symptoms	Galfalvy, 2009	patients only	P-value=0.045	Lower cerebrospinal fluid MHPG(3-methoxy-4-hydroxphenylglyco...... Lower cerebrospinal fluid MHPG(3-methoxy-4-hydroxphenylglycol) predicted future suicide attempt or suicide (22% increase in hazard for each 10 pmol/ml lower MHPG, p=0.045). Lower CSF MHPG also correlated with higher medical lethality of future suicidal act (mean MHPG: 49+/-18 vs. 32+/-12 pmol/ml for low- vs. high-lethality, t=2.8, d.f.=25, p=0.009). More...

Positive relationship network of Methoxyhydroxyphenylglycol in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationship between Methoxyhydroxyphenylglycol and MDD (count: 0)

Negative relationships between Methoxyhydroxyphenylglycol and other components at different levels (count: 0)