Gene Report

Basic Information

Approved Symbol	ADAR
Approved Name	adenosine deaminase, RNA-specific
Previous Symbol	IFI4, G1P1
Previous Name	interferon-induced protein 4
Symbol Alias	ADAR1
Location	1q21.3
Position	chr1:154554533-154600456 (-)
External Links	Entrez Gene: 103 Ensembl: ENSG00000160710 UCSC: uc001ffh.3 HGNC ID: 225
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ADAR and MDD (count: 0)

Positive relationships between ADAR and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
ADAR1		Suicide(suicide)	symptoms	Simmons, 2010	patients and normal controls		ADAR1 expression was found to be significantly increased in ...... ADAR1 expression was found to be significantly increased in major depressive suicide victims compared with patients who did not commit suicide. More...

Positive relationship network of ADAR in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ADAR and MDD (count: 0)

Negative relationships between ADAR and other components at different levels (count: 0)

ADAR related SNPs in MK4MDD (count: 0)

ADAR related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Double-stranded RNA-specific adenosine deaminase	P55265	0(0/0)	Gene mapped

ADAR related GO terms (count: 27)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006397	mRNA processing	biological process	IEA
GO:0010467	gene expression	biological process	TAS
GO:0046872	metal ion binding	molecular function	IEA
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS
GO:0060337	type I interferon-mediated signaling pathway	biological process	TAS
GO:0051607	defense response to virus	biological process	IEA
GO:0016556	mRNA modification	biological process	TAS
GO:0043066	negative regulation of apoptotic process	biological process	IEA
GO:0006611	protein export from nucleus	biological process	IDA[19124606]
GO:0044530	supraspliceosomal complex	cellular component	IDA[18362360]
GO:0035455	response to interferon-alpha	biological process	IDA[16475990]
GO:0006382	adenosine to inosine editing	biological process	IDA[15858013]; IMP[16475990]; TAS
GO:0016553	base conversion or substitution editing	biological process	IDA[9020165]
GO:0005654	nucleoplasm	cellular component	TAS
GO:0003677	DNA binding	molecular function	IEA
GO:0005634	nucleus	cellular component	IDA; TAS[7565688]
GO:0006606	protein import into nucleus	biological process	IDA[19124606]
GO:0045070	positive regulation of viral genome replication	biological process	IDA[19651874]; IMP[18362360]
GO:0005515	protein binding	molecular function	IPI[19124606]
GO:0003725	double-stranded RNA binding	molecular function	IEA
GO:0005737	cytoplasm	cellular component	IDA[19124606]; TAS[7565688]
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	biological process	IDA[19651874]; IMP[18362360]
GO:0045087	innate immune response	biological process	TAS[16475990]
GO:0031047	gene silencing by RNA	biological process	IEA
GO:0005730	nucleolus	cellular component	IEA
GO:0009615	response to virus	biological process	IMP[15858013]
GO:0003726	double-stranded RNA adenosine deaminase activity	molecular function	IDA[9020165]; NAS[7565688]

ADAR related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04623	cytosolic dna_sensing_pathway	Cytosolic DNA-sensing pathway	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell. More...

ADAR related BioCarta pathways (count: 0)

ADAR related Reactome pathways (count: 1)

Gene mapped Reactome pathways
ID	Name	Description
REACT_1675	mrna processing	Processing of mRNA encompasses the capping of mRNA, processi...... Processing of mRNA encompasses the capping of mRNA, processing of mRNAs with and without introns, and also modification of mRNA, as in mRNA editing. More...

ADAR related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ADAR	ADAR	Yes	in vitro	10364558
ADAR	HDLBP	No	in vitro	15723802
ADAR	XPO1	No	in vitro;in vivo	11604520

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways