Gene Report

Basic Information

Approved Symbol	S100A10
Approved Name	S100 calcium binding protein A10
Previous Symbol	ANX2LG, CAL1L
Previous Name	S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)), "S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))"
Symbol Alias	P11, 42C, CLP11
Name Alias	annexin II tetramer (AIIt) p11 subunit
Location	1q21
Position	chr1:151955386-151966714 (-)
External Links	Entrez Gene: 6281 Ensembl: ENSG00000197747 UCSC: uc001ezl.3 HGNC ID: 10487
No. of Studies (Positive/Negative)	3(1/2)
Type	Literature-origin; Protein mapped

Positive relationships between S100A10 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
p11	Su, 2009	patients and normal controls		We found that patients with PTSD had lower levels of p11 mRN...... We found that patients with PTSD had lower levels of p11 mRNA than control subjects, while those with MDD, BP and SCZ had significantly higher p11 levels than the controls. More...

Positive relationships between S100A10 and other components at different levels (count: 0)

Positive relationship network of S100A10 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between S100A10 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
p11	Verma R, 2007	Patients and nomal controls		Resequencing revealed nine novel rare variants, including a...... Resequencing revealed nine novel rare variants, including a missense mutation (Asp60Glu) observed in one case and one control, and four variants that occurred only in cases and not controls. The number of rare variants in cases did not exceed that expected by chance for the length of sequence analyzed, and also was not significantly greater than that observed in controls. Resequencing also identified two known SNPs, one (rs4845720) of which was significantly more frequent in cases than controls in the resequenced sample (3.1% vs. 0.9%, P = 0.03), though not in the larger sample (3% vs. 2%, P = 0.15). None of the tag SNPs showed any evidence of association. More...
S100A10	Tzang RF, 2008	Patients and nomal controls		No significant association with MDD was discovered in single...... No significant association with MDD was discovered in single locus or haplotype analyses. More...

Negative relationships between S100A10 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
S100A10		Suicide(suicide attempt)	symptoms	Tzang RF, 2008	Patients and nomal controls		No significant association with suicide attempt was shown in...... No significant association with suicide attempt was shown in both the alleles and genotypes of single loci or of haplotypes constructed from these three p11 polymorphisms More...

S100A10 related SNPs in MK4MDD (count: 0)

S100A10 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Protein S100-A10	P60903	1(1/0)	Literature-origin

S100A10 related GO terms (count: 6)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0019897	extrinsic to plasma membrane	cellular component	IEA
GO:0007165	signal transduction	biological process	NAS[1831433]
GO:0005102	receptor binding	molecular function	NAS[1831433]
GO:0051099	positive regulation of binding	biological process	IEA
GO:0005509	calcium ion binding	molecular function	IEA
GO:0071229	cellular response to acid	biological process	IEA

S100A10 related KEGG pathways (count: 0)

S100A10 related BioCarta pathways (count: 0)

S100A10 related Reactome pathways (count: 0)

S100A10 related interactors from protein-protein interaction data in HPRD (count: 11)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
S100A10	BAD	No	in vivo;yeast 2-hybrid	9369453
S100A10	ANXA2	No	in vitro	8898866 , 2148288 , 12660155
S100A10	ANXA7	No	in vitro	1533123
S100A10	CTSB	Yes	in vitro;yeast 2-hybrid	10777578
S100A10	S100A10	Yes	in vitro	9886297 , 17254974
S100A10	KCNK3	No	in vitro;in vivo;yeast 2-hybrid	12198146
S100A10	FSHR	No	yeast 2-hybrid	15196694
S100A10	COPS6	No	yeast 2-hybrid	16169070
S100A10	SETDB1	Yes	yeast 2-hybrid	16169070
S100A10	TRPV6	No	in vitro	12660155
S100A10	PLG	No	in vitro	11939791

Gene Report

Gene mapped GO terms