Study Report
Reference
| Citation | Lehto, 2008 PubMed |
| Full Info | Lehto, S.M., Tolmunen, T., Kuikka, J., Valkonen-Korhonen, M., Joensuu, M., Saarinen, P.I., Vanninen, R., Ahola, P., Tiihonen, J. and Lehtonen, J. (2008) Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study. Neurosci Lett, 441, 291-295.
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Study
| Hypothesis or Background |
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| Sample Information | 8DD(co-occurrence of major depression and dysthymia)[6 female,mean age=23.4(±4.6)]; 11 MDD[11 female,mean age=31.3(±5.9)]; 19 normal controls[16 female,mean age=30.6(±8.9)]. All patients underwent one year of psychotherapy starting either immediately after inclusion in the study or after a six-month waiting period. |
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| Method Detail | We examined the striatum dopamine (DAT) and midbrain serotonin transporter (SERT) binding of [123I] nor-beta-CIT in DD patients (n=8) and compared it to that in MD patients (n=11) and healthy controls (n=19). Drug-naive patients and controls were imaged by single-photon emission computed tomography at baseline, and the patients also after one year of psychodynamic psychotherapy. |
| Method Keywords | single photon emission computed tomography (SPECT) |
| Result | Both DD and MD groups had lower midbrain [123I] nor-beta-CIT binding compared with the controls. Baseline 17-item Hamilton Depression Rating Scale (HAM-D-17) scores significantly decreased in both groups after one year of psychotherapy (DD: t=3.55, p=0.009; MD: t=5.86, p<0.001). No differences between the DD and MD groups were observed in age-adjusted baseline striatum or midbrain [123I] nor-beta-CIT binding or its change during psychotherapy. Age-adjusted baseline striatum [123I] nor-beta-CIT binding correlated inversely with the duration of both dysthymia (rho=-0.76, p=0.03) and MD (rho=-0.83, p=0.01) in the DD group. No such finding was observed in the MD group (rho=0.26, p=0.44). Baseline HAM-D-17 did not correlate with the change in striatum or midbrain [123I] nor-beta-CIT binding in either group. |
| Conclusions | In conclusion, our findings suggest that when using midbrain [123I] nor-beta-CIT binding as a marker of SERT binding, no differences are detectable between patients with DD and MD. However, low striatum [123I] nor-beta-CIT binding, a marker of DAT binding, may be associated with a longer illness duration in dysthymia. |
Relationships reported by
Lehto, 2008
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
Midbrain (midbrain) |
brain morphology and function |
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Major depression groups had lower midbrain [123I] nor-beta-CIT(a selective dopamine transporter imaging agent) binding compared with the controls. |
Positive
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MDD
|
syndrome |
Sodium-dependent dopamine transporter (dopamine transporter) |
protein |
|
Major depression groups had lower midbrain [123I] nor-beta-CIT(a selective dopamine transporter imaging agent) binding compared with the controls. |
Positive
|
|
Midbrain (midbrain)
|
brain morphology and function |
Sodium-dependent dopamine transporter (dopamine transporter) |
protein |
|
Major depression groups had lower midbrain [123I] nor-beta-CIT(a selective dopamine transporter imaging agent) binding compared with the controls. |
Positive
|
