Study Report
Reference
| Citation | Meltzer, 2004 PubMed |
| Full Info | Meltzer, C.C., Price, J.C., Mathis, C.A., Butters, M.A., Ziolko, S.K., Moses-Kolko, E., Mazumdar, S., Mulsant, B.H., Houck, P.R., Lopresti, B.J. et al. (2004) Serotonin 1A receptor binding and treatment response in late-life depression. Neuropsychopharmacology, 29, 2258-2265.
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Study
| Hypothesis or Background |
Depression in late life carries an increased risk of dementia and brittle response to treatment. There is growing evidence to support a key role of the serotonin type 1A (5-HT(1A)) receptor as a regulator of treatment response, particularly the 5-HT(1A) autoreceptor in the dorsal raphe nucleus (DRN).
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| Sample Information | We studied 17 elderly subjects with untreated (nonpsychotic, nonbipolar) major depression (four men, 13 women; mean age: 71.4+/-5.9) and 17 healthy control subjects (eight men, nine women; mean age: 70.0+/-6.7). |
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| Method Detail | We used [11C]WAY 100635 and positron emission tomography (PET) to test our hypothesis that 5-HT(1A) receptor binding in the DRN and prefrontal cortex is altered in elderly depressives and that these measures relate to treatment responsivity. Patients were subsequently treated with paroxetine as part of a clinical trial of maintenance therapies in geriatric depression. [11C]WAY 100635 PET imaging was acquired and binding potential (BP) values derived using compartmental modeling. |
| Method Keywords | positron emission tomography (PET) |
| Result | We observed significantly diminished [11C]WAY 100635 binding in the DRN in depressed (BP = 2.31+/-0.90) relative to control (BP = 3.69+/-1.56) subjects (p = 0.0016). Further, the DRN BP was correlated with pretreatment Hamilton Depression Rating Scores (r = 0.60, p = 0.014) in the depressed cohort. A trend level correlation between DRN binding and time to remission (r = 0.52, p = 0.067) was observed in the 14 depressed patients for whom these data were available. |
| Conclusions | Our finding of decreased [11C]WAY 100635 binding in the brainstem region of the DRN in elderly depressed patients supports evidence of altered 5-HT(1A) autoreceptor function in depression. Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression. |
Relationships reported by
Meltzer, 2004
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Depressed mood (depression)
|
symptoms |
Dorsal raphe nucleus (dorsal raphe nucleus) |
brain morphology and function |
r = 0.60, P-value = 0.014 |
the DRN(dorsal raphe nucleus) BP(5-HT(1A) receptor binding ) was correlated with pretreatment Hamilton Depression Rating Scores (r = 0.60, p = 0.014) in the depressed cohort. |
Positive
|
|
MDD
|
syndrome |
Dorsal raphe nucleus (dorsal raphe nucleus) |
brain morphology and function |
P-value = 0.0016 |
We used [11C]WAY 100635 and positron emission tomography (PET) to test our hypothesis that 5-HT(1A) receptor binding, We observed significantly diminished [11C]WAY 100635 binding in the DRN (dorsal raphe nucleus) in depressed (BP = 2.31+/-0.90) relative to control (BP = 3.69+/-1.56) subjects (p = 0.0016). |
Positive
|
|
Depressed mood (depression)
|
symptoms |
5-hydroxytryptamine receptor 1A (5-HT(1A) receptor) |
protein |
r = 0.60, P-value = 0.014 |
the DRN(dorsal raphe nucleus) BP(5-HT(1A) receptor binding ) was correlated with pretreatment Hamilton Depression Rating Scores (r = 0.60, p = 0.014) in the depressed cohort. |
Positive
|
|
MDD
|
syndrome |
5-hydroxytryptamine receptor 1A (5-HT(1A) receptor) |
protein |
P-value = 0.0016 |
We used [11C]WAY 100635 and positron emission tomography (PET) to test our hypothesis that 5-HT(1A) receptor binding, We observed significantly diminished [11C]WAY 100635 binding in the DRN (dorsal raphe nucleus) in depressed (BP = 2.31+/-0.90) relative to control (BP = 3.69+/-1.56) subjects (p = 0.0016). |
Positive
|
