Study Report
Reference
| Citation | Cho, 2010 PubMed |
| Full Info | Cho, Z.H., Kim, Y.B., Han, J.Y., Kim, N.B., Hwang, S.I., Kim, S.J. and Cho, S.J. (2010) Altered T2* relaxation time of the hippocampus in major depressive disorder: implications of ultra-high field magnetic resonance imaging. J Psychiatr Res, 44, 881-886.
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Study
| Hypothesis or Background |
Previous studies with 1.5 T or 3.0 T magnetic resonance imaging (MRI) have produced mixed results regarding the structural changes of the hippocampus in major depressive disorder (MDD). Subtle region-specific hippocampal tissue changes might be more sensitively detected by measuring the T2* relaxation time (T2*-RT) by ultra-high-field (UHF) MRI, as it provides much higher contrast and sensitivity and consequently greater resolution.
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| Sample Information | 16 MDD patients (9 with recurrent MDD) and 16 control subjects |
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| Method Detail | We assessed the T2*-RTs of hippocampal sub-regions in 16 MDD patients (9 with recurrent MDD) and 16 control subjects using an UHF 7.0 T MRI system. T2*-RTs of CA1, CA2, CA3, CA4, and subiculum were calculated for both left and right hippocampus. |
| Method Keywords | magnetic resonance imaging (MRI) |
| Result | MDD patients had significantly longer T2*-RTs in the right CA1 and subiculum than control subjects. Patients with recurrent MDD had significantly longer T2*-RTs in the right subiculum than those experiencing a first depressive episode, and longer T2*-RTs in the right CA1, CA3, and subiculum than control subjects. Values for T2*-RTs of the right CA3 were significantly correlated with illness duration. In conclusion, we report that T2*-RTs in the right subiculum and CA1 were increased in patients with MDD, especially in cases of recurrent MDD. |
| Conclusions | These findings suggest that region-specific hippocampal damage may be occurring in recurrent depression. |
Relationships reported by
Cho, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
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syndrome |
Hippocampus (hippocampus) |
brain morphology and function |
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T2*-RTs(T2* relaxation time) of hippocampal sub-regions (CA1, CA2, CA3, CA4, and subiculum) were calculated for both left and right hippocampus.Patients with recurrent MDD had significantly longer T2*-RTs in the right subiculum than those experiencing a first depressive episode, and longer T2*-RTs in the right CA1, CA3, and subiculum than control subjects. |
Positive
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