|Citation||Cho, 2010 PubMed
|Full Info||Cho, Z.H., Kim, Y.B., Han, J.Y., Kim, N.B., Hwang, S.I., Kim, S.J. and Cho, S.J. (2010) Altered T2* relaxation time of the hippocampus in major depressive disorder: implications of ultra-high field magnetic resonance imaging. J Psychiatr Res, 44, 881-886.
|Hypothesis or Background
Previous studies with 1.5 T or 3.0 T magnetic resonance imaging (MRI) have produced mixed results regarding the structural changes of the hippocampus in major depressive disorder (MDD). Subtle region-specific hippocampal tissue changes might be more sensitively detected by measuring the T2* relaxation time (T2*-RT) by ultra-high-field (UHF) MRI, as it provides much higher contrast and sensitivity and consequently greater resolution.
|Sample Information||16 MDD patients (9 with recurrent MDD) and 16 control subjects |
|Method Detail||We assessed the T2*-RTs of hippocampal sub-regions in 16 MDD patients (9 with recurrent MDD) and 16 control subjects using an UHF 7.0 T MRI system. T2*-RTs of CA1, CA2, CA3, CA4, and subiculum were calculated for both left and right hippocampus.
|Method Keywords||magnetic resonance imaging (MRI)
|Result||MDD patients had significantly longer T2*-RTs in the right CA1 and subiculum than control subjects. Patients with recurrent MDD had significantly longer T2*-RTs in the right subiculum than those experiencing a first depressive episode, and longer T2*-RTs in the right CA1, CA3, and subiculum than control subjects. Values for T2*-RTs of the right CA3 were significantly correlated with illness duration. In conclusion, we report that T2*-RTs in the right subiculum and CA1 were increased in patients with MDD, especially in cases of recurrent MDD.
|Conclusions||These findings suggest that region-specific hippocampal damage may be occurring in recurrent depression.
Relationships reported by Cho, 2010