SNP Report

Name	rs9939609 dbSNP Ensembl
Location	Chrchr16:53786615(Forward)
Variant Alleles	T/A
Ancestral Allele	A
No. of Studies (Positive/Negative)	2 (1/1)

Reference	Research Type	Statistical Result	Relation Description
Samaan Z, 2012	patients and normal controls	odds ratio=0.92 (0.89, 0.97), P-value =3 x 10(-4)	A meta-analysis of the four studies showed a significant inv...... A meta-analysis of the four studies showed a significant inverse association between the obesity risk FTO rs9939609 A variant and depression (odds ratio=0.92 (0.89, 0.97), P=3 x 10(-4)) adjusted for age, sex, ethnicity/population structure and body-mass index (BMI) with no significant between-study heterogeneity (I(2)=0%, P=0.63). More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Reference	Research Type	Statistical Result	Relation Description
Du, 2015	Patients and nomal controls	P(allele)=0.5586£»P(genotype)=0.6641	SNP rs12936694 in the ALKBH5 locus was strongly associated w...... SNP rs12936694 in the ALKBH5 locus was strongly associated with MDD (uncorrected p=0.0008, OR=1.491,95%CI 1.179¨C1.887), with a global p value of 0.0036 after 10,000 permutations (Table 2). Genotypic association was detected for rs12936694 ( METTL3 locus showed a weak association with MDD (uncorrected ¦Ö2=12.26, df=2, p=0.0022). SNP rs17197156 in the p=0.0156, OR=1.2610, 95%CI 1.045¨C1.522), but such an association did not survive a correction with 10,000 permutations (global p=0.0790). There was no allelic association of rs9939609 in the FTO with MDD (¦Ö2=0.3422, p=0.5586). More...