Study Report
Reference
| Citation | Xia, 2004 PubMed |
| Full Info | Xia, J., Chen, J., Zhou, Y., Zhang, J., Yang, B., Xia, L. and Wang, C. (2004) Volumetric MRI analysis of the amygdala and hippocampus in subjects with major depression. J Huazhong Univ Sci Technolog Med Sci, 24, 500-502, 506.
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Study
| Hypothesis or Background |
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| Sample Information | 22 patients with major depression and compared with 13 age-matched controls |
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| Method Detail | In order to explore the MRI volume of the amygdala and hippocampus in patients with major depression, quantitative MRI of the amygdala and hippocampus were studied in 22 patients with major depression and compared with 13 age-matched controls. |
| Method Keywords | magnetic resonance imaging (MRI) |
| Result | The results showed that both groups exhibited similar significant hippocampal asymmetry (left smaller than right). The volume of the bilateral hippocampus was significantly smaller in the major depression group than that in control group. The patients had significant asymmetry of the amygdalar volumes (right smaller than left). No correlation was found between hippocampal volume abnormalities and ill duration. |
| Conclusions | It was concluded that the hippocampus and amygdala within limbic-cortical networks may play a crucial role in the pathogenesis of major depression. |
Relationships reported by
Xia, 2004
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Amygdala (amygdala) |
brain morphology and function |
|
The patients had significant asymmetry of the amygdalar volumes (right smaller than left). |
Positive
|
|
MDD
|
syndrome |
Hippocampus (hippocampus) |
brain morphology and function |
|
The volume of the bilateral hippocampus was significantly smaller in the major depression group than that in control group. |
Positive
|
