Neurobiological Component Report

Name	N400
Description	The N400 is a component of time-locked EEG signals known as event-related potentials (ERP). It is a negative-going deflection that peaks around 400 milliseconds post-stimulus onset, although it can extend from 250-500 ms, and is typically maximal over centro-parietal electrode sites.
Picture	Source
No. of Studies (Positive/Negative)	5 (5/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
N450	McNeely, 2008	patients and normal controls		A negative displacement (N450) at parietal sites for positiv...... A negative displacement (N450) at parietal sites for positive and negative words only for persons with MDD. More...
N450	Holmes, 2008	patients and normal controls		Compared to healthy controls, MDD subjects showed reduced N4...... Compared to healthy controls, MDD subjects showed reduced N450 amplitudes. More...
N400	Ortiz, 2003	patients and normal controls		The depressive patients showed increased event-related poten...... The depressive patients showed increased event-related potentials (N400) between 300-700 milliseconds registered in Pz. More...
N400	Iakimova, 2009	patients and normal controls		Patients exhibited prolonged latency of the N400 in semantic...... Patients exhibited prolonged latency of the N400 in semantic judgment More...
N450	Dai, 2011	patients and normal controls		Both the MDD and RMD participants (depressed patients who we...... Both the MDD and RMD participants (depressed patients who were currently in remission) showed enhanced negativity (N450) over the parietal regions of the brain for negative words compared with control participants. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
N450		Automatic processing(negative automatic thinking)	cognition and behavior	McNeely, 2008	patients and normal controls		The N450 modulation correlated with negative automatic think...... The N450 modulation correlated with negative automatic thinking and depressive symptoms. More...
N400		Accuracy for reaction(lower accuracy)	cognition and behavior	Iakimova, 2009	patients and normal controls		In patients lower accuracy was correlated with more prolonge...... In patients lower accuracy was correlated with more prolonged N400 latency and more negative N400 amplitude for congruous sentence endings. More...
N450		Depressed mood(depressed mood)	symptoms	McNeely, 2008	patients and normal controls		The N450 modulation correlated with negative automatic think...... The N450 modulation correlated with negative automatic thinking and depressive symptoms. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web