Study Report
Reference
| Citation | Messa, 2003 PubMed |
| Full Info | Messa, C., Colombo, C., Moresco, R.M., Gobbo, C., Galli, L., Lucignani, G., Gilardi, M.C., Rizzo, G., Smeraldi, E., Zanardi, R. et al. (2003) 5-HT(2A) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study. Psychopharmacology (Berl), 167, 72-78.
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Study
| Hypothesis or Background |
The aim of the study was to investigate differences in 5-HT(2A) receptor binding between healthy volunteers and patients with major depressive disorder (MDD), either never treated before with antidepressants (drug-naive: DN) or responding to paroxetine treatment (drug-treated: DT).
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| Sample Information | nineteen DN patients with MDD and 15 euthymic DT (paroxetine 4 weeks) patients were compared with a group of 20 healthy controls (C) |
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| Method Detail | Nineteen DN patients with MDD and 15 euthymic DT (paroxetine 4 weeks) patients were compared with a group of 20 healthy controls (C) with positron emission tomography (PET) using [(18)F]fluoroethylspiperone ([(18)F]FESP), a 5-HT(2A) and D(2) receptor antagonist. A binding index (BI) of [(18)F]FESP to cortical and basal ganglia regions was calculated as the ratio of the activity in these regions to that of cerebellum. Differences in BI between groups, i.e. C versus DN or DT, were assessed by ANOVA, with or without age as covariate (ANCOVA). |
| Method Keywords | positron emission tomography (PET) |
| Result | A significant reduction in BI ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN patients in the frontal, occipital, temporal and cingulate cortices, but not in the striatum. No significant differences emerged between C and DT patients. |
| Conclusions | The reduction of [(18)F]FESP BI in cortical areas of DN depressed, but not of euthymic DT patients suggests an association between the occurrence of depressive symptoms and impairment of cortical 5-HT(2A) receptors. [(18)F]FESP cortical BI may represent a state marker of depression. |
Relationships reported by
Messa, 2003
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Temporal Lobe (temporal cortices) |
brain morphology and function |
P-value = 0.003 ANOVA; P-value = 0.001 ANCOVA |
A significant reduction in binding index (BI) of [(18)F]FESP ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN(drug-naive) patients in the frontal, occipital, temporal and cingulate cortices |
Positive
|
|
MDD
|
syndrome |
Occipital Lobe (occipital cortices) |
brain morphology and function |
P-value = 0.003 ANOVA; P-value = 0.001 ANCOVA |
A significant reduction in binding index (BI) of [(18)F]FESP ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN(drug-naive) patients in the frontal, occipital, temporal and cingulate cortices |
Positive
|
|
MDD
|
syndrome |
5-hydroxytryptamine receptor 2A (5-HT(2A) receptors) |
protein |
|
The reduction of [(18)F]FESP BI in cortical areas of DN depressed, but not of euthymic DT patients suggests an association between the occurrence of depressive symptoms and impairment of cortical 5-HT(2A) receptors. |
Positive
|
|
MDD
|
syndrome |
Frontal Lobe (frontal cortices) |
brain morphology and function |
P-value = 0.003 ANOVA; P-value = 0.001 ANCOVA |
A significant reduction in binding index (BI) of [(18)F]FESP ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN(drug-naive) patients in the frontal, occipital, temporal and cingulate cortices |
Positive
|
|
MDD
|
syndrome |
Cingulate cortex (cingulate cortices) |
brain morphology and function |
P-value = 0.003 ANOVA; P-value = 0.001 ANCOVA |
A significant reduction in binding index (BI) of [(18)F]FESP ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN(drug-naive) patients in the frontal, occipital, temporal and cingulate cortices |
Positive
|
