Study Report
Reference
| Citation | Ottowitz, 2010 PubMed |
| Full Info | Ottowitz, W.E., Deckersbach, T., Savage, C.R., Lindquist, M.A. and Dougherty, D.D. (2010) Neural correlates of strategic processes underlying episodic memory in women with major depression: A 15O-PET study. J Neuropsychiatry Clin Neurosci, 22, 218-230.
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Study
| Hypothesis or Background |
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| Sample Information | eight healthy females, IQ=122, and eight depressed females, IQ=107 |
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| Method Detail | To evaluate the functional integrity of brain regions underlying strategic mnemonic processing in patients with major depressive disorder, the authors administered a modified version of the California Verbal Learning Test to depressed patients during presentation of lists of unrelated words and, conversely, during presentation of lists of related words with and without orientation regarding the relatedness of the words. |
| Method Keywords | positron emission tomography (PET) |
| Result | Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of the right anterior cingulate cortex, left ventrolateral prefrontal cortex, both hippocampi, and the left orbitofrontal cortex. Further analysis showed that patients with major depressive disorder had greater activation of the right anterior cingulate cortex during semantic organization and the right ventrolateral prefrontal cortex during strategy initiation. |
Relationships reported by
Ottowitz, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Language (semantic organization)
|
cognition and behavior |
right anterior cingulate cortex (right anterior cingulate cortex) |
brain morphology and function |
|
Further analysis showed that patients with major depressive disorder had greater activation of the right anterior cingulate cortex during semantic organization. |
Positive
|
|
Cognitive control (strategy initiation)
|
cognition and behavior |
right ventrolateral prefrontal cortex (right ventrolateral prefrontal cortex) |
brain morphology and function |
|
Further analysis showed that patients with major depressive disorder had greater activation of the right ventrolateral prefrontal cortex during strategy initiation |
Positive
|
|
MDD
|
syndrome |
left orbitofrontal cortex (left orbitofrontal cortex) |
brain morphology and function |
|
Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of the left orbitofrontal cortex. |
Positive
|
|
MDD
|
syndrome |
Hippocampus (hippocampi) |
brain morphology and function |
|
Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of both hippocampi. |
Positive
|
|
MDD
|
syndrome |
ventrolateral prefrontal cortex (ventrolateral prefrontal cortex) |
brain morphology and function |
|
Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of the left ventrolateral prefrontal cortex. Further analysis showed that patients with major depressive disorder had greater activation of the right ventrolateral prefrontal cortex during strategy initiation. |
Positive
|
|
MDD
|
syndrome |
right anterior cingulate cortex (right anterior cingulate cortex) |
brain morphology and function |
|
Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of the right anterior cingulate cortex. Further analysis showed that patients with major depressive disorder had greater activation of the right anterior cingulate cortex during semantic organization. |
Positive
|
