MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Shah, 1997 PubMed
Full Info	Shah, P.J., Ogilvie, A.D., Goodwin, G.M. and Ebmeier, K.P. (1997) Clinical and psychometric correlates of dopamine D2 binding in depression. Psychol Med, 27, 1247-1256.

Study

Hypothesis or Background	Single photon emission tomography (SPET) with the dopamine D2/3 ligand 123I-IBZM gives a semi-quantitative estimate of dopamine binding. In depressed patients, we predicted evidence of reduced function, i.e. increased binding, particularly in more retarded patients.
Sample Information	Fifteen depressed patients with major depressive illness (9 males and 6 females) and 15 healthy, age- and sex- matched volunteers. Eight patients were on antidepressant medication (including lithium) only, three were on benzodiazepines only, the remaining four were free of all medication.
Method Detail	Fifteen depressed patients with major depressive illness and 15 healthy, age- and sex- matched volunteers were examined with a clinical and neuropsychological test battery and high resolution IBZM-SPET. Estimates for specific binding were computed by averaging striatum to whole slice or frontal uptake ratios over 8-10 scans acquired from 70 min after tracer injection.
Method Keywords	single photon emission computed tomography (SPECT); psychometric method
Result	Using whole slice as reference, left striatal uptake ratios did not significantly differ for patients from controls. Right ratios were significantly higher in patients than controls (P = 0.03). There were significant correlations between IBZM binding in left and right striatum and measures of reaction time and verbal fluency.
Conclusions	Increased IBZM binding in striatum probably reflects reduced dopamine function, whether due to reduced release of dopamine, or secondary up-regulation of receptors. The observed abnormalities may be trait or state related, an issue that needs to be addressed with longitudinal study designs. The possible role of medication as a confounding variable requires further exploration.

Relationships reported by Shah, 1997

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
MDD	syndrome	D(3) dopamine receptor (dopamine D3 receptor)	protein		Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls.	Positive
Reaction time (reaction time)	cognition and behavior	Striatum (striatum)	brain morphology and function		There were significant correlations between 123I-IBZM (dopamine D2/3 ligand) binding in left and right striatum and measures of reaction time.	Positive
MDD	syndrome	left striatal region (left striatal region)	brain morphology and function		Using whole slice as reference, left striatal uptake ratios did not significantly differ for patients from controls.	Negative
Language (verbal fluency)	cognition and behavior	Striatum (striatum)	brain morphology and function		There were significant correlations between 123I-IBZM (dopamine D2/3 ligand) binding in left and right striatum and measures of verbal fluency.	Positive
right striatum (right striatal region)	brain morphology and function	D(2) dopamine receptor (dopamine D2 receptor)	protein		Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls.	Positive
MDD	syndrome	right striatum (right striatal region)	brain morphology and function	P-value = 0.03	Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls.	Positive
Reaction time (reaction time)	cognition and behavior	D(2) dopamine receptor (dopamine D2 receptor)	protein		There were significant correlations between 123I-IBZM (dopamine D2/3 ligand) binding in left and right striatum and measures of reaction time.	Positive
right striatum (right striatal region)	brain morphology and function	D(3) dopamine receptor (dopamine D3 receptor)	protein		Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls.	Positive
Reaction time (reaction time)	cognition and behavior	D(3) dopamine receptor (dopamine D3 receptor)	protein		There were significant correlations between 123I-IBZM (dopamine D2/3 ligand) binding in left and right striatum and measures of reaction time.	Positive
Language (verbal fluency)	cognition and behavior	D(2) dopamine receptor (dopamine D2 receptor)	protein		There were significant correlations between 123I-IBZM (dopamine D2/3 ligand) binding in left and right striatum and measures of verbal fluency.	Positive
MDD	syndrome	D(2) dopamine receptor (dopamine D2 receptor)	protein		Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls.	Positive
Language (verbal fluency)	cognition and behavior	D(3) dopamine receptor (dopamine D3 receptor)	protein		There were significant correlations between 123I-IBZM (dopamine D2/3 ligand) binding in left and right striatum and measures of verbal fluency.	Positive