MK4MDD

Brain Morphology and Function Report

Basic Information
Name Striatum
Brain Morphology "The striatum is a subcortical part of the forebrain. It is the major input station of the basal ganglia system. The striatum, in turn, gets input from the cerebral cortex. In primates (including humans), the striatum is divided by a white matter tract called the internal capsule into two sectors called the caudate nucleus and putamen."
Brain Function "Metabotropic dopamine receptors are present both on spiny neurons and on cortical axon terminals. Second messenger cascades triggered by activation of these dopamine receptors can modulate pre- and postsynaptic function, both in the short term and in the long term. The striatum is best known for its role in the planning and modulation of movement pathways but is also involved in a variety of other cognitive processes involving executive function. In humans the striatum is activated by stimuli associated with reward, but also by aversive, novel, unexpected or intense stimuli, and cues associated with such events. "
Picture Striatum From Wiki. Magnify
No. of Studies (Positive/Negative) 12(12/0) Help

Positive relationships between Striatum and MDD (count: 7)
Name in Literature Reference Research Type Statistical Result Relation Description Help
striatal regions Forbes, 2009 patients and normal controls Adolescents with major depressive disorder exhibited less st...... Adolescents with major depressive disorder exhibited less striatal response than healthy comparison adolescents during reward anticipation and reward outcome. More...
striatal regions Smoski, 2009 patients and normal controls The MDD group was characterized by reduced activation of str...... The MDD group was characterized by reduced activation of striatal reward regions during reward selection, reward anticipation, and reward feedback. More...
striatal region Dougherty, 2006 patients and normal controls [(11)C]SCH 23,390 binding in bilateral striata was signific...... [(11)C]SCH 23,390 binding in bilateral striata was significantly lower in the MDD+A group when compared to healthy volunteers. These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression. More...
striatum Cannon, 2007 patients and normal controls increased 5-HTT BP in the striatum (12%) Relative to the healthy group both MDD and BD groups showed ...... Relative to the healthy group both MDD and BD groups showed significantly increased 5-HTT BP in the striatum (12%). More...
striatum Wu, 2011 patients and normal controls The authors found the 99mTc-TRODAT-1 radio signal in the str...... The authors found the 99mTc-TRODAT-1 radio signal in the striatum was reduced in the majority of patients with major depressive disorder, More...
limbic-striatal regions Jiao, 2011 patients and normal controls Resting brain activity levels measured by ALFF was higher in...... Resting brain activity levels measured by ALFF was higher in the frontal cortex than that in the subcortical system involving mainly (para) limbic-striatal regions in both HC and MDD adolescents. More...
striatal region Robinson, 2012 patients and normal controls Impaired reward (but not punishment) reversal accuracy was f...... Impaired reward (but not punishment) reversal accuracy was found alongside attenuated anteroventral striatal response to unexpected reward in depression. More...

Positive relationships between Striatum and other components at different levels (count: 9) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Striatum in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Striatum and MDD (count: 0)
Negative relationships between Striatum and other components at different levels (count: 0) Help