Study Report
Reference
| Citation | Hosokawa, 2009 PubMed |
| Full Info | Hosokawa, T., Momose, T. and Kasai, K. (2009) Brain glucose metabolism difference between bipolar and unipolar mood disorders in depressed and euthymic states. Prog Neuropsychopharmacol Biol Psychiatry, 33, 243-250.
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Study
| Hypothesis or Background |
Functional brain imaging studies have consistently demonstrated abnormalities in regional cerebral glucose metabolism in the prefrontal cortex in patients with mood disorders (MD). These studies, however, have not clarified the differential characteristics of glucose metabolism between depressed and euthymic states, or between bipolar mood disorder (BP) and unipolar mood disorder (UP).
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| Sample Information | 30 depressed (bipolar mood disorder and unipolar mood disorder) and 17 euthymic female patients with mood disorders with age-, IQ-, and socioeconomically matched 20 healthy controls (HCs). |
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| Method Detail | We used [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET) to evaluate the differences in glucose metabolism at resting state. We compared 30 depressed and 17 euthymic female patients with mood disorders with age-, IQ-, and socioeconomically matched 20 healthy controls (HCs). Then, BP and UP patients were separately analyzed. The PET data were objectively analyzed by statistical parametric mapping (SPM). |
| Method Keywords | positron emission tomography (PET) |
| Result | Compared with HCs, the depressed MD patients showed significantly lower glucose metabolism in the bilateral frontal gyri, left cingulate gyrus, bilateral temporal gyri, right insula, bilateral inferior parietal lobules, and right occipital gyrus. In contrast, the euthymic MD patients demonstrated fewer areas with significant reduction. When the depressed BP patients were separately compared with HCs, the glucose metabolism was found to be significantly lower in the bilateral frontal gyri, right cingulate gyrus, and bilateral inferior parietal lobules. Meanwhile, the depressed UP patients showed a significantly lower metabolism in the bilateral frontal gyri, left cingulate gyrus, bilateral temporal gyri, bilateral insulae, bilateral inferior parietal lobules, and right occipital gyrus. |
| Conclusions | The results of this study provide evidence of persistent hypometabolism in depressed MD patients, particularly in the frontal gyrus. Although the conclusions are limited in the cross-sectional study, these findings suggest that abnormalities in the right frontal gyrus, left temporal gyrus, and left cingulate gyrus tend to normalize as the depression symptoms improve, although those in the left frontal gyrus, right cingulate gyrus, and right temporal gyrus persist. This study also elucidated the cerebral hypofunction specific to each BP and UP. BP patients showed a decrease in glucose metabolism in the right anterior cingulate and UP patients did in the right temporal gyrus, right insula, and left posterior cingulate. This study clarified the differences between subtypes. |
Relationships reported by
Hosokawa, 2009
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
right occipital gyrus (right occipital gyrus) |
brain morphology and function |
|
Compared with healthy controls, the depressed UP (unipolar mood disorder) patients showed significantly lower glucose metabolism in the right occipital gyrus. |
Positive
|
|
MDD
|
syndrome |
left cingulate gyrus (left cingulate gyrus) |
brain morphology and function |
|
Compared with healthy controls, the depressed UP (unipolar mood disorder) patients showed significantly lower glucose metabolism in the left cingulate gyrus. |
Positive
|
|
MDD
|
syndrome |
bilateral temporal gyri (bilateral temporal gyri) |
brain morphology and function |
|
Compared with healthy controls, the depressed UP (unipolar mood disorder) patients showed significantly lower glucose metabolism in the bilateral temporal gyri. |
Positive
|
|
MDD
|
syndrome |
Inferior parietal lobule (bilateral inferior parietal lobules) |
brain morphology and function |
|
Compared with healthy controls, the depressed UP (unipolar mood disorder) patients showed significantly lower glucose metabolism in the bilateral inferior parietal lobules. |
Positive
|
|
MDD
|
syndrome |
Insula (bilateral insula) |
brain morphology and function |
|
Compared with healthy controls, the depressed UP (unipolar mood disorder) patients showed significantly lower glucose metabolism in the bilateral insula. |
Positive
|
|
MDD
|
syndrome |
Frontal Lobe (bilateral frontal gyri) |
brain morphology and function |
|
Compared with healthy controls, the depressed UP (unipolar mood disorder) patients showed significantly lower glucose metabolism in the bilateral frontal gyri. |
Positive
|
