MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Klimek, 2002 PubMed
Full Info	Klimek, V., Schenck, J.E., Han, H., Stockmeier, C.A. and Ordway, G.A. (2002) Dopaminergic abnormalities in amygdaloid nuclei in major depression: a postmortem study. Biol Psychiatry, 52, 740-748.

Study

Hypothesis or Background	A deficiency of mesolimbic dopamine (DA) is a leading candidate for the etiology of certain symptoms of depression (e.g., anhedonia and loss of motivation). Here we show amounts of dopaminergic proteins in the amygdala, a key brain structure involved in the integration of emotions and stress, in subjects with major depression and in psychiatrically normal control subjects.
Sample Information	11 subjects with major depression and 11 matched control subjects.
Method Detail	The specific binding of [(125)I]RTI 55 to the DA transporter, [(3)H]SCH 23390 to the D1 receptor and [(125)I]epidepride to D2/D3 receptors were measured in the right amygdaloid complex in postmortem brains from 11 subjects with major depression and 11 matched control subjects.
Method Keywords	postmortem study; immunocytochemical analysis; autoradiographic method
Result	The binding of [(125)I]RTI 55 to DA transporter was significantly lower in the basal and central amygdaloid nuclei, whereas the binding of [(125)I]epidepride to D2/D3 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects. No difference in the binding of [(3)H]SCH 23390 to D1 receptors was observed.
Conclusions	Given that DA depletion in rats can induce a reduction in the DA transporter and an upregulation of D2/D3 receptors, our data are consistent with the hypothesis that major depression is associated with a deficiency of mesolimbic DA.

Relationships reported by Klimek, 2002

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
MDD	syndrome	Sodium-dependent dopamine transporter (dopamine transporter)	protein		The binding of [(125)I]RTI 55 to DA (dopamine) transporter was significantly lower in the basal and central amygdaloid nuclei in major depression compared with control subjects.	Positive
MDD	syndrome	Amygdala (amygdaloid nuclei)	brain morphology and function		The binding of [(125)I]RTI 55 to DA (dopamine) transporter was significantly lower in the basal and central amygdaloid nuclei in major depression compared with control subjects. The binding of [(125)I]epidepride to D2 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects. The binding of [(125)I]epidepride to D3 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects.	Positive
Amygdala (amygdaloid nuclei)	brain morphology and function	D(3) dopamine receptor (dopamine D3 receptor)	protein		The binding of [(125)I]epidepride to D3 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects.	Positive
Amygdala (amygdaloid nuclei)	brain morphology and function	D(2) dopamine receptor (dopamine D2 receptor)	protein		The binding of [(125)I]epidepride to D2 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects.	Positive
MDD	syndrome	D(1A) dopamine receptor (dopamine D1 receptor)	protein		No difference in the binding of [(3)H]SCH 23390 to D1 receptors was observed.	Negative
MDD	syndrome	D(3) dopamine receptor (dopamine D3 receptor)	protein		The binding of [(125)I]epidepride to D3 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects.	Positive
MDD	syndrome	D(2) dopamine receptor (dopamine D2 receptor)	protein		The binding of [(125)I]epidepride to D2 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects.	Positive
Central amygdaloid nuclei (central amygdaloid nuclei)	brain morphology and function	Sodium-dependent dopamine transporter (dopamine transporter)	protein		The binding of [(125)I]RTI 55 to DA (dopamine) transporter was significantly lower in the basal and central amygdaloid nuclei in major depression compared with control subjects.	Positive
Basal amygdaloid nuclei (basal amygdaloid nuclei)	brain morphology and function	Sodium-dependent dopamine transporter (dopamine transporter)	protein		The binding of [(125)I]RTI 55 to DA (dopamine) transporter was significantly lower in the basal and central amygdaloid nuclei in major depression compared with control subjects.	Positive