MK4MDD

Brain Morphology and Function Report

Basic Information
Name Habenula
Brain Morphology "In neuroanatomy, habenula originally denoted the stalk of the pineal gland (pineal habenula; pedunculus of pineal body), but gradually came to refer to a neighboring group of nerve cells with which the pineal gland was believed to be associated, the habenular nucleus. The habenular nucleus is a set of well conserved structures in all vertebrate animals. Currently, the Terminologia Anatomica term refers exclusively to this separate cell mass in the caudal and dorsal aspect of the dorsal thalamus (the epithalamus), embedded in the posterior end of the medullary stria from which it receives most of its afferent fibers. By way of the retroflex fasciculus (habenulointerpeduncular tract) it projects to the interpeduncular nucleus and other paramedian cell groups of the midbrain tegmentum."
Brain Function "The habenular nuclei have been shown to be involved in many functions, including pain processing, reproductive behavior, nutrition, sleep-wake cycles, stress responses, and learning. Recent demonstrations using fMRI and single unit electrophysiology have closely linked the function of the lateral habenula with reward processing, in particular with regard to encoding negative feedback or negative rewards. Matsumoto and Hikosaka suggested in 2007 that this reward and reward-negative information in the brain might ""be elaborated through the interplay among the lateral habenula, the basal ganglia, and monoaminergic (dopaminergic and serotonergic) systems"" and that the lateral habenula may play a pivotal role in this ""integrative function"". Both the medial and lateral habenula show reduced volume in those with depression. Neuron cell numbers were also reduced on the right side. Such changes not seen in those with schizophrenia. Deep brain stimulation of the major afferent bundle (i.e., stria medullaris thalami) of the lateral hebenuala has been used for treatment of depression where it is severe, protracted and therapy-resistant."
Picture Habenula From Wiki. Magnify
No. of Studies (Positive/Negative) 3(3/0) Help

Positive relationships between Habenula and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
habenula Roiser, 2009 patients and normal controls Following ATD (acute tryptophan depletion), habenula blood f...... Following ATD (acute tryptophan depletion), habenula blood flow increased significantly in the rMDD subjects relative to the control subjects. More...
habenula Savitz, 2011 patients and normal controls P-value < .05 In post hoc assessments analyzing men and women separately, ...... In post hoc assessments analyzing men and women separately, the currently-depressed women with MDD had smaller absolute (p < .05) habenula volumes than the HC (healthy control subjects) women. More...

Positive relationships between Habenula and other components at different levels (count: 3) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Habenula in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Habenula and MDD (count: 0)
Negative relationships between Habenula and other components at different levels (count: 0) Help