Gene Report

Basic Information

Approved Symbol	NLGN1
Approved Name	neuroligin 1
Symbol Alias	KIAA1070
Location	3q26.32
Position	chr3:173116244-174001116 (+)
External Links	Entrez Gene: 22871 Ensembl: ENSG00000169760 UCSC: uc003fio.1 HGNC ID: 14291
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between NLGN1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NLGN1	Lewis, 2010	patients and normal controls	P-value <10 -5	associated with MDD(P <10 -5) associated with MDD(P <10 -5)

Positive relationships between NLGN1 and other components at different levels (count: 0)

Positive relationship network of NLGN1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NLGN1 and MDD (count: 0)

Negative relationships between NLGN1 and other components at different levels (count: 0)

NLGN1 related SNPs in MK4MDD (count: 0)

NLGN1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Neuroligin-1	Q8N2Q7	0(0/0)	Gene mapped

NLGN1 related GO terms (count: 49)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0045211	postsynaptic membrane	cellular component	IEA
GO:0030054	cell junction	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0014069	postsynaptic density	cellular component	TAS[15797875]
GO:0016339	calcium-dependent cell-cell adhesion	biological process	ISS
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	biological process	ISS
GO:0051290	protein heterotetramerization	biological process	IEA
GO:0060999	positive regulation of dendritic spine development	biological process	ISS
GO:0002087	regulation of respiratory gaseous exchange by neurological system process	biological process	IEA
GO:0097105	presynaptic membrane assembly	biological process	ISS
GO:0051491	positive regulation of filopodium assembly	biological process	ISS
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	ISS
GO:0097115	neurexin clustering	biological process	ISS
GO:0005887	integral to plasma membrane	cellular component	IBA; ISS
GO:0045664	regulation of neuron differentiation	biological process	ISS
GO:1900029	positive regulation of ruffle assembly	biological process	ISS
GO:0032230	positive regulation of synaptic transmission, GABAergic	biological process	ISS
GO:0046983	protein dimerization activity	molecular function	ISS
GO:0042043	neurexin family protein binding	molecular function	IBA; ISS
GO:0097104	postsynaptic membrane assembly	biological process	ISS
GO:0023041	neuronal signal transduction	biological process	TAS[15797875]
GO:0072553	terminal button organization	biological process	ISS
GO:0009986	cell surface	cellular component	IBA; ISS
GO:0007158	neuron cell-cell adhesion	biological process	ISS; TAS[15797875]
GO:0006605	protein targeting	biological process	ISS
GO:1900244	positive regulation of synaptic vesicle endocytosis	biological process	ISS
GO:0097114	N-methyl-D-aspartate receptor clustering	biological process	IEA
GO:0004872	receptor activity	molecular function	IBA; ISS
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	cellular component	IEA
GO:0007157	heterophilic cell-cell adhesion	biological process	ISS
GO:0010740	positive regulation of intracellular protein kinase cascade	biological process	ISS
GO:0048789	cytoskeletal matrix organization at active zone	biological process	ISS
GO:2000463	positive regulation of excitatory postsynaptic membrane potential	biological process	ISS
GO:0097091	synaptic vesicle clustering	biological process	ISS
GO:0016080	synaptic vesicle targeting	biological process	ISS
GO:0007399	nervous system development	biological process	ISS
GO:0004091	carboxylesterase activity	molecular function	IKR
GO:0007416	synapse assembly	biological process	IBA; ISS
GO:0030425	dendrite	cellular component	ISS
GO:0097120	receptor localization to synapse	biological process	ISS
GO:0051965	positive regulation of synapse assembly	biological process	ISS
GO:0032433	filopodium tip	cellular component	IEA
GO:0045184	establishment of protein localization	biological process	ISS
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	biological process	ISS
GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering	biological process	ISS
GO:2000302	positive regulation of synaptic vesicle exocytosis	biological process	ISS
GO:0051260	protein homooligomerization	biological process	ISS
GO:0045202	synapse	cellular component	IBA; ISS
GO:0097119	postsynaptic density protein 95 clustering	biological process	ISS
GO:0050839	cell adhesion molecule binding	molecular function	ISS

NLGN1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04514	cell adhesion_molecules_cams	Cell adhesion molecules (CAMs)	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cellcell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways

NLGN1 related BioCarta pathways (count: 0)

NLGN1 related Reactome pathways (count: 0)

NLGN1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NLGN1	DLG4	Yes	in vitro;yeast 2-hybrid	9278515
NLGN1	NRXN1	No	in vitro	8576240 , 14522992

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways