Study Report
Reference
| Citation | Grimm, 2011 PubMed |
| Full Info | Grimm, S., Ernst, J., Boesiger, P., Schuepbach, D., Boeker, H. and Northoff, G. (2011) Reduced negative BOLD responses in the default-mode network and increased self-focus in depression. World J Biol Psychiatry.
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Study
| Hypothesis or Background |
Functional imaging studies in major depressive disorder (MDD) indicate abnormal resting state neural activity and negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network (DMN).
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| Sample Information | 25 patients with MDD and 25 healthy controls |
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| Method Detail | Since activity in DMN regions has been associated with self-relatedness, we investigated neural activity in these regions during self-related emotional judgement and passive picture viewing in 25 patients with MDD and 25 healthy controls in an event-related fMRI design. |
| Method Keywords | functional magnetic resonance imaging (fMRI) |
| Result | Behaviourally, MDD subjects showed significantly higher ratings of self-relatedness that also correlated with depression symptoms such as hopelessness. Neuroimaging results in MDD patients showed significantly lower negative BOLD responses (NBRs) in anterior medial cortical regions during judgement of self-relatedness while posterior medial regions showed increased NBRs. Unlike in healthy subjects, the anterior medial cortical NBRs were no longer parametrically modulated by the degree of self-relatedness in MDD patients. |
| Conclusions | Our findings suggest that reduced NBRs in the anterior regions of the default-mode network may signify decoupling from self-relatedness in MDD patients with the consecutive abnormal increase of self-focus. |
Relationships reported by
Grimm, 2011
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
anterior medial cortical regions (anterior medial cortical regions) |
brain morphology and function |
|
Neuroimaging results in MDD patients showed significantly lower negative BOLD responses (NBRs) in anterior medial cortical regions during judgement of self-relatedness while posterior medial regions showed increased NBRs. |
Positive
|
|
MDD
|
syndrome |
Attribution and attitude (higher ratings of self-relatedness) |
cognition and behavior |
|
Behaviourally, MDD subjects showed significantly higher ratings of self-relatedness that also correlated with depression symptoms such as hopelessness. |
Positive
|
|
MDD
|
syndrome |
Posterior medial regions (posterior medial regions) |
brain morphology and function |
|
Neuroimaging results in MDD patients showed significantly lower negative BOLD responses (NBRs) in anterior medial cortical regions during judgement of self-relatedness while posterior medial regions showed increased NBRs. |
Positive
|
|
Feelings of hopelessness, worthlessness, and guilt (hopelessness)
|
symptoms |
Attribution and attitude (higher ratings of self-relatedness) |
cognition and behavior |
|
Behaviourally, MDD subjects showed significantly higher ratings of self-relatedness that also correlated with depression symptoms such as hopelessness. |
Positive
|
