|Citation||MacMaster, 2008 PubMed
|Full Info||MacMaster, F.P., Mirza, Y., Szeszko, P.R., Kmiecik, L.E., Easter, P.C., Taormina, S.P., Lynch, M., Rose, M., Moore, G.J. and Rosenberg, D.R. (2008) Amygdala and hippocampal volumes in familial early onset major depressive disorder. Biol Psychiatry, 63, 385-390.
|Hypothesis or Background
Abnormalities in the amygdala and hippocampus have been implicated in the pathogenesis of major depressive disorder (MDD). To our knowledge, no prior study has examined amygdala-hippocampus anatomy in pediatric patients with familial MDD (at least one first degree relative with MDD).
|Sample Information||Thirty-two psychotropic-naive patients with familial MDD, aged 8-21 years (12 males and 20 females), and 35 group-matched healthy participants (13 males and 22 females) |
|Method Detail||Subjects underwent volumetric magnetic resonance imaging in order to evaluate hippocampal and amygdala volumes.
|Method Keywords||magnetic resonance imaging (MRI)
|Result||Patients with familial MDD had significantly smaller left hippocampal (p = .007, effect size [d] = .44) and right hippocampal volumes (p = .025, d = .33) than controls. No differences were noted in amygdala volumes between groups (right: p > .05, left: p > .05). No correlations between hippocampal or amygdala volumes and demographic or clinical variables were noted.
|Conclusions||Reduced hippocampal volume may be suggestive of a risk factor for developing MDD.
Relationships reported by MacMaster, 2008