Study Report

CitationMacMaster, 2008 PubMed
Full InfoMacMaster, F.P., Mirza, Y., Szeszko, P.R., Kmiecik, L.E., Easter, P.C., Taormina, S.P., Lynch, M., Rose, M., Moore, G.J. and Rosenberg, D.R. (2008) Amygdala and hippocampal volumes in familial early onset major depressive disorder. Biol Psychiatry, 63, 385-390.

Hypothesis or Background Abnormalities in the amygdala and hippocampus have been implicated in the pathogenesis of major depressive disorder (MDD). To our knowledge, no prior study has examined amygdala-hippocampus anatomy in pediatric patients with familial MDD (at least one first degree relative with MDD).
Sample InformationThirty-two psychotropic-naive patients with familial MDD, aged 8-21 years (12 males and 20 females), and 35 group-matched healthy participants (13 males and 22 females)
Method DetailSubjects underwent volumetric magnetic resonance imaging in order to evaluate hippocampal and amygdala volumes.
Method Keywordsmagnetic resonance imaging (MRI)
ResultPatients with familial MDD had significantly smaller left hippocampal (p = .007, effect size [d] = .44) and right hippocampal volumes (p = .025, d = .33) than controls. No differences were noted in amygdala volumes between groups (right: p > .05, left: p > .05). No correlations between hippocampal or amygdala volumes and demographic or clinical variables were noted.
ConclusionsReduced hippocampal volume may be suggestive of a risk factor for developing MDD.

Relationships reported by MacMaster, 2008