Protein Report

Protein Name	Interleukin-5
UniPortKB	P05113
No. of Studies (Positive/Negative)	2 (1/1)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IL-5	Elomaa AP, 2012	patients and normal controls	OR 1.76, 95% CI 1.03-2.99, P-value = 0.04	In our basic multivariate model controlling for the effects ...... In our basic multivariate model controlling for the effects of potential confounders on the associations between MDD and the examined cytokines, each 1-unit increase in the serum IL-5 level increased the likelihood of belonging to the MDD group by 76% (OR 1.76, 95% CI 1.03-2.99, p = 0.04; model covariates: age, gender, marital status, daily smoking and alcohol use). More...

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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
interleukin-5	Einvik G, 2012	patients and normal controls		Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
IL5	interleukin 5 (colony-stimulating factor, eosinophil)	Literature-origin; Protein mapped	1 (1/0)