Study Report
Reference
| Citation | Hasler, 2007 PubMed |
| Full Info | Hasler, G., Bonwetsch, R., Giovacchini, G., Toczek, M.T., Bagic, A., Luckenbaugh, D.A., Drevets, W.C. and Theodore, W.H. (2007) 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression. Biol Psychiatry, 62, 1258-1264.
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Study
| Hypothesis or Background |
Major depressive disorder (MDD) is the most common comorbid psychiatric condition associated with temporal lobe epilepsy (TLE). Preclinical and clinical studies suggest that 5-HT(1A) receptors play a role in the pathophysiology of both TLE and MDD. There is preliminary evidence for an association between decreased 5-HT(1A) receptor binding in limbic brain areas and affective symptoms in TLE patients. The objective of this study was to compare 5-HT(1A) receptor binding between TLE patients with and without MDD. For the first time, 5-HT(1A) receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews.
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| Sample Information | Thirty-seven temporal lobe epilepsy (TLE) patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews |
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| Method Detail | Thirty-seven epilepsy patients with temporal lobe foci confirmed by ictal video-electroencephalogram (EEG) monitoring were recruited from the Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke. We performed interictal positron emission tomography scanning, with [(18)F]FCWAY, a fluorinated derivative of WAY100635, on a GE Medical Systems (Waukesha, Wisconsin) Advance scanner with continuous EEG monitoring. The 5-HT(1A) receptor binding was estimated by partial volume-corrected [(18)F]FCWAY V/f(1) values. |
| Method Keywords | electroencephalogram (EEG); positron emission tomography (PET) |
| Result | In addition to decreased 5-HT(1A) receptor binding in the epileptic focus itself, comorbid MDD was associated with a significantly more pronounced reduction in 5-HT(1A) receptor binding in TLE patients, extending into non-lesional limbic brain areas outside the epileptic focus. Focus side and the presence of mesial temporal sclerosis were not associated with the presence of comorbid depression. |
| Conclusions | Reductions in 5-HT(1A) receptor binding might help elucidate the neurobiological mechanisms underlying the TLE-MDD comorbidity. |
Relationships reported by
Hasler, 2007
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
Limbic lobe (limbic brain areas) |
brain morphology and function |
|
Comorbid MDD was associated with a significantly more pronounced reduction in 5-HT(1A) receptor binding in TLE ( temporal lobe epilepsy) patients, extending into non-lesional limbic brain areas outside the epileptic focus. |
Positive
|
|
MDD
|
syndrome |
Temporal Lobe (temporal lobe) |
brain morphology and function |
|
Comorbid MDD was associated with a significantly more pronounced reduction in 5-HT(1A) receptor binding in TLE ( temporal lobe epilepsy) patients, extending into non-lesional limbic brain areas outside the epileptic focus. |
Positive
|
|
MDD
|
syndrome |
5-hydroxytryptamine receptor 1A (5-HT(1A) receptor) |
protein |
|
Comorbid MDD was associated with a significantly more pronounced reduction in 5-HT(1A) receptor binding in TLE ( temporal lobe epilepsy) patients. Reductions in 5-HT(1A) receptor binding might help elucidate the neurobiological mechanisms underlying the TLE-MDD comorbidity. |
Positive
|
