Component A Approved Name (Name in Paper) 
Component A Type 
Component B Approved Name (Name in Paper) 
Component B Type 
Statistical Result 
Relationship Description 
Result Category (Positive/Negative)) 
MDD

syndrome 
rs644926 (rs644926) 
SNP 
Pvalue = 0.007 
The conditional test showed disease association for the rs619002(EHD3)rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)rs1112714(T) combination (OR = 0, P = 4.02 x 10(6) ) and for the rs644926(A)rs11938298(G) combination (OR = 0.12, 95% CI = 0.0350.39, P = 3.85 x 10(6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). 
Positive

MDD

syndrome 
rs1112714 (rs1112714) 
SNP 
Pvalue = 0.0059 
The conditional test showed disease association for the rs619002(EHD3)rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)rs1112714(T) combination (OR = 0, P = 4.02 x 10(6) ) and for the rs644926(A)rs11938298(G) combination (OR = 0.12, 95% CI = 0.0350.39, P = 3.85 x 10(6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). 
Positive

MDD

syndrome 
rs13130123 (rs13130123) 
SNP 
Pvalue = 0.007 
The conditional test showed disease association for the rs619002(EHD3)rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)rs1112714(T) combination (OR = 0, P = 4.02 x 10(6) ) and for the rs644926(A)rs11938298(G) combination (OR = 0.12, 95% CI = 0.0350.39, P = 3.85 x 10(6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). 
Positive

rs644926 (rs644926)

SNP 
rs13130123 (rs13130123) 
SNP 
Pvalue = 0.007 
The conditional test showed disease association for the rs619002(EHD3)rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)rs1112714(T) combination (OR = 0, P = 4.02 x 10(6) ) and for the rs644926(A)rs11938298(G) combination (OR = 0.12, 95% CI = 0.0350.39, P = 3.85 x 10(6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). 
Positive

rs1112714 (rs1112714)

SNP 
rs619002 (rs619002) 
SNP 
Pvalue = 0.0059 
The conditional test showed disease association for the rs619002(EHD3)rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)rs1112714(T) combination (OR = 0, P = 4.02 x 10(6) ) and for the rs644926(A)rs11938298(G) combination (OR = 0.12, 95% CI = 0.0350.39, P = 3.85 x 10(6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). 
Positive

MDD

syndrome 
rs619002 (rs619002) 
SNP 
Pvalue = 0.0059 
The conditional test showed disease association for the rs619002(EHD3)rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)rs1112714(T) combination (OR = 0, P = 4.02 x 10(6) ) and for the rs644926(A)rs11938298(G) combination (OR = 0.12, 95% CI = 0.0350.39, P = 3.85 x 10(6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). 
Positive

rs13130123 (rs13130123)

SNP 
rs644926 (rs644926) 
SNP 
Pvalue = 0.007 
The conditional test showed disease association for the rs619002(EHD3)rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)rs1112714(T) combination (OR = 0, P = 4.02 x 10(6) ) and for the rs644926(A)rs11938298(G) combination (OR = 0.12, 95% CI = 0.0350.39, P = 3.85 x 10(6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). 
Positive

MDD

syndrome 
EHD3 (EHD3) 
gene 

Of the 16 genes tested, EHD3 and FREM3 were associated with MDD in the Chinese population. 
Positive

rs619002 (rs619002)

SNP 
rs1112714 (rs1112714) 
SNP 
Pvalue = 0.0059 
The conditional test showed disease association for the rs619002(EHD3)rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)rs1112714(T) combination (OR = 0, P = 4.02 x 10(6) ) and for the rs644926(A)rs11938298(G) combination (OR = 0.12, 95% CI = 0.0350.39, P = 3.85 x 10(6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). 
Positive

MDD

syndrome 
FREM3 (FREM3) 
gene 

Of the 16 genes tested, EHD3 and FREM3 were associated with MDD in the Chinese population. 
Positive
