Gene Report

Basic Information

Approved Symbol	FREM3
Approved Name	FRAS1 related extracellular matrix 3
Location	4q31.21
Position	chr4:144498560-144621828 (-)
External Links	Entrez Gene: 166752 Ensembl: ENSG00000183090 UCSC: uc021xsj.1 HGNC ID: 25172
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; SNP mapped

Positive relationships between FREM3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
FREM3	Shi C, 2012	patients and normal controls		Of the 16 genes tested, EHD3 and FREM3 were associated with ...... Of the 16 genes tested, EHD3 and FREM3 were associated with MDD in the Chinese population. More...

Positive relationships between FREM3 and other components at different levels (count: 0)

Positive relationship network of FREM3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between FREM3 and MDD (count: 0)

Negative relationships between FREM3 and other components at different levels (count: 0)

FREM3 related SNPs in MK4MDD (count: 3)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs1112714	chr4:144503647(Forward)	intron_variant; nc_transcript_variant	1(1/0)
rs13130123	chr4:144508588(Forward)	intron_variant; nc_transcript_variant	1(1/0)
rs7676614	chr4:144616366(Forward)	intron_variant	1(0/1)

FREM3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
FRAS1-related extracellular matrix protein 3	P0C091	0(0/0)	Gene mapped

FREM3 related GO terms (count: 6)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005604	basement membrane	cellular component	IEA
GO:0016021	integral to membrane	cellular component	IEA
GO:0046872	metal ion binding	molecular function	IEA
GO:0031012	extracellular matrix	cellular component	TAS
GO:0007155	cell adhesion	biological process	IEA
GO:0007154	cell communication	biological process	IEA

FREM3 related KEGG pathways (count: 0)

FREM3 related BioCarta pathways (count: 0)

FREM3 related Reactome pathways (count: 0)

FREM3 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms