Gene Report

Basic Information

Approved Symbol	CCBL2
Approved Name	cysteine conjugate-beta lyase 2
Symbol Alias	RBM1, RP11-82K18.3, KAT3
Location	1p22.2
Position	chr1:89401456-89458643 (-)
External Links	Entrez Gene: 56267 Ensembl: ENSG00000137944 UCSC: uc001dmp.2 HGNC ID: 33238
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CCBL2 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
KAT III	Claes, 2011	patients and normal controls	P-value<0.001	The frequencies of SNP haplotype CGCTCT of KAT III gene in p...... The frequencies of SNP haplotype CGCTCT of KAT III gene in patients with major depression showed significantly higher than the control population (p<0.001) More...
CCBL2	Claes, 2011	patients and normal controls	P-value<0.001	The frequencies of this haplotype CGCTCT (rs12729558-rs17130...... The frequencies of this haplotype CGCTCT (rs12729558-rs17130657-rs1325924-rs2038905-rs7556189-rs7517036) in major depression showed significantly higher than the control population (p<0.001). More...

Positive relationships between CCBL2 and other components at different levels (count: 0)

Positive relationship network of CCBL2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CCBL2 and MDD (count: 0)

Negative relationships between CCBL2 and other components at different levels (count: 0)

CCBL2 related SNPs in MK4MDD (count: 0)

CCBL2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Kynurenine--oxoglutarate transaminase 3	Q6YP21	0(0/0)	Gene mapped

CCBL2 related GO terms (count: 13)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006520	cellular amino acid metabolic process	biological process	ISS
GO:0030170	pyridoxal phosphate binding	molecular function	IEA
GO:0005739	mitochondrion	cellular component	IEA
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS
GO:0016212	kynurenine-oxoglutarate transaminase activity	molecular function	ISS
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0006569	tryptophan catabolic process	biological process	TAS
GO:0070189	kynurenine metabolic process	biological process	ISS
GO:0047315	kynurenine-glyoxylate transaminase activity	molecular function	ISS
GO:0047804	cysteine-S-conjugate beta-lyase activity	molecular function	IEA
GO:0042803	protein homodimerization activity	molecular function	IEA
GO:0009058	biosynthetic process	biological process	IEA
GO:0006103	2-oxoglutarate metabolic process	biological process	IEA

CCBL2 related KEGG pathways (count: 0)

CCBL2 related BioCarta pathways (count: 0)

CCBL2 related Reactome pathways (count: 0)

CCBL2 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Gene mapped GO terms