Gene Report

Basic Information

Approved Symbol	MLC1
Approved Name	megalencephalic leukoencephalopathy with subcortical cysts 1
Symbol Alias	MLC, KIAA0027, LVM, VL
Location	22q13.33
Position	chr22:50497820-50524358 (-)
External Links	Entrez Gene: 23209 Ensembl: ENSG00000100427 UCSC: uc003bjg.1 HGNC ID: 17082
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between MLC1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
MLC1	Spijker, 2010	patients and normal controls		Based on LPS-stimulated blood gene expression using whole-ge...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More...

Positive relationships between MLC1 and other components at different levels (count: 0)

Positive relationship network of MLC1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between MLC1 and MDD (count: 0)

Negative relationships between MLC1 and other components at different levels (count: 0)

MLC1 related SNPs in MK4MDD (count: 0)

MLC1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Membrane protein MLC1	Q15049	0(0/0)	Gene mapped

MLC1 related GO terms (count: 28)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005768	endosome	cellular component	IDA[18165104]
GO:0047484	regulation of response to osmotic stress	biological process	IMP
GO:0055037	recycling endosome	cellular component	ISS
GO:0006811	ion transport	biological process	IEA
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA
GO:0005886	plasma membrane	cellular component	IDA
GO:0016323	basolateral plasma membrane	cellular component	IDA[18165104]
GO:0005737	cytoplasm	cellular component	IDA[15892299]
GO:0045121	membrane raft	cellular component	ISS
GO:0016021	integral to membrane	cellular component	IDA[17628813]
GO:0031410	cytoplasmic vesicle	cellular component	IDA[19931615]
GO:0005764	lysosome	cellular component	ISS
GO:0016192	vesicle-mediated transport	biological process	ISS
GO:0051259	protein oligomerization	biological process	IDA[15367490]
GO:0005901	caveola	cellular component	ISS
GO:0016324	apical plasma membrane	cellular component	IEA
GO:0005911	cell-cell junction	cellular component	IEA
GO:0006810	transport	biological process	NAS[11254442]
GO:0005515	protein binding	molecular function	IPI[19931615]
GO:0032403	protein complex binding	molecular function	IDA[17628813]
GO:0005783	endoplasmic reticulum	cellular component	IDA
GO:0008565	protein transporter activity	molecular function	ISS
GO:0072584	caveolin-mediated endocytosis	biological process	ISS
GO:0005769	early endosome	cellular component	ISS
GO:0005215	transporter activity	molecular function	NAS[11254442]
GO:0032388	positive regulation of intracellular transport	biological process	IDA[19931615]
GO:0071397	cellular response to cholesterol	biological process	ISS
GO:0030136	clathrin-coated vesicle	cellular component	ISS

MLC1 related KEGG pathways (count: 0)

MLC1 related BioCarta pathways (count: 0)

MLC1 related Reactome pathways (count: 0)

MLC1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
MLC1	TPT1	No	in vitro;in vivo;yeast 2-hybrid	12149273
MLC1	DAPK2	No	in vitro	10376525

Gene Report

Gene mapped GO terms