Molecule Report

Name	Norepinephrine
Description	Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
MeSH ID	D009638
No. of Studies (Positive/Negative)	4(4/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
noradrenaline	Kelly, 1998	patients and normal controls		The melancholic/psychotic depressed group had the highest pl...... The melancholic/psychotic depressed group had the highest plasma NA levels. This only reached statistical significance with respect to the control group. More...
norepinephrine	Ferguson, 2002	patients only		Reboxetine is the first selective norepinephrine reuptake in...... Reboxetine is the first selective norepinephrine reuptake inhibitor (NRI) approved for the treatment of major depressive disorder (MDD). More...
norepinephrine	Koenigsberg, 2004	patients and normal controls		The depressed patients had phase advanced circadian rhythms ...... The depressed patients had phase advanced circadian rhythms for cortisol, norepinephrine and MHPG, phase advanced hemicircadian rhythms for cortisol and prolactin, and a phase advanced ultradian rhythm for prolactin compared to healthy control subjects. In addition, the rhythm-corrected 24-h mean value (mesor) of norepinephrine was lower in the depressed patients compared to the healthy controls. There also was a poorer goodness-of-fit for norepinephrine to the circadian oscillator in the depressed patients relative to the healthy controls. More...
noradrenaline	Mata, 2005	patients and normal controls		Also there was a relative greater concentration of noradrena...... Also there was a relative greater concentration of noradrenaline than serotonin in the lymphocytes of the patients, as indicated by the ratio noradrenaline/serotonin. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
norepinephrine		Cognitive performance(cognitive disturbance)	cognition and behavior	Ferguson, 2002	patients only		Reboxetine, a selective NRI(norepinephrine reuptake inhibito...... Reboxetine, a selective NRI(norepinephrine reuptake inhibitor), improves symptoms of psychomotor retardation, anxiety and cognitive disturbance during treatment of MDD. Cognitive disturbance and anxiety were improved in three of four trials. More...
norepinephrine		Increased agitation(anxiety)	symptoms	Ferguson, 2002	patients only		Reboxetine, a selective NRI(norepinephrine reuptake inhibito...... Reboxetine, a selective NRI(norepinephrine reuptake inhibitor), improves symptoms of psychomotor retardation, anxiety and cognitive disturbance during treatment of MDD. Cognitive disturbance and anxiety were improved in three of four trials. More...
norepinephrine		Low energy(psychomotor retardation)	symptoms	Ferguson, 2002	patients only		Reboxetine, a selective NRI(norepinephrine reuptake inhibito...... Reboxetine, a selective NRI(norepinephrine reuptake inhibitor), improves symptoms of psychomotor retardation, anxiety and cognitive disturbance during treatment of MDD. Compared to placebo, reboxetine significantly improved psychomotor retardation in all four trials. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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