Study Report
Reference
| Citation | Lee, 2008 PubMed |
| Full Info | Lee, B.T., Seok, J.H., Lee, B.C., Cho, S.W., Yoon, B.J., Lee, K.U., Chae, J.H., Choi, I.G. and Ham, B.J. (2008) Neural correlates of affective processing in response to sad and angry facial stimuli in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry, 32, 778-785.
|
Study
| Hypothesis or Background |
Mood abnormalities related to major depressive disorder (MDD) seem to result from disturbances in pathways connecting the fronto-limbic and subcortical, both regions known to be involved in the processing of emotional information.
|
| Sample Information | 21 patients with MDD and 15 healthy controls |
|---|
| Method Detail | Using functional magnetic resonance imaging (fMRI), we measured neural responses to viewing images of sad, angry and neutral faces in 21 patients with MDD and 15 healthy controls. |
| Method Keywords | functional magnetic resonance imaging (fMRI) |
| Result | When shown pictures of sad faces, patients with MDD relative controls showed decreased activations bilaterally in the dorsolateral prefrontal cortex, inferior orbitofrontal cortex (OFC), medial OFC, caudate, and hippocampus. We also found significant group differences under the angry face condition, bilaterally, in the inferior OFC and medial OFC areas. |
| Conclusions | Our findings indicate that decreased activations in the fronto-limbic and subcortical regions in response to affectively negative stimuli may be associated with pathophysiology of MDD. |
Relationships reported by
Lee, 2008
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
inferior orbitofrontal cortex (inferior orbitofrontal cortex (OFC)) |
brain morphology and function |
|
When shown pictures of sad faces, patients with MDD relative controls showed decreased activations bilaterally in the inferior orbitofrontal cortex (OFC). We also found significant group differences under the angry face condition, bilaterally, in the inferior OFC. |
Positive
|
|
MDD
|
syndrome |
Hippocampus (hippocampus) |
brain morphology and function |
|
When shown pictures of sad faces, patients with MDD relative controls showed decreased activations bilaterally in the hippocampus. |
Positive
|
|
MDD
|
syndrome |
Dorsolateral prefrontal cortex (dorsolateral prefrontal cortex) |
brain morphology and function |
|
When shown pictures of sad faces, patients with MDD relative controls showed decreased activations bilaterally in the dorsolateral prefrontal cortex. |
Positive
|
|
MDD
|
syndrome |
Caudate nucleus (caudate) |
brain morphology and function |
|
When shown pictures of sad faces, patients with MDD relative controls showed decreased activations bilaterally in the caudate. |
Positive
|
|
MDD
|
syndrome |
medial orbitofrontal cortex (medial orbitofrontal cortex (OFC)) |
brain morphology and function |
|
When shown pictures of sad faces, patients with MDD relative controls showed decreased activations bilaterally in the medial OFC. We also found significant group differences under the angry face condition, bilaterally, in the medial OFC areas. |
Positive
|
