|Citation||Frodl, 2004 PubMed
|Full Info||Frodl, T., Meisenzahl, E.M., Zetzsche, T., Hohne, T., Banac, S., Schorr, C., Jager, M., Leinsinger, G., Bottlender, R., Reiser, M. et al. (2004) Hippocampal and amygdala changes in patients with major depressive disorder and healthy controls during a 1-year follow-up. J Clin Psychiatry, 65, 492-499.
|Hypothesis or Background
Although the hippocampus has been found to be smaller in patients with depression, prospective longitudinal in vivo studies are necessary to investigate whether depression can result in a further diminution of hippocampal volumes or whether a smaller hippocampal volume predisposes an individual to the development of depression.
|Sample Information||thirty patients with DSM-IV major depressive disorder as well as 30 healthy control subjects matched for age, gender, and handedness|
|Method Detail||Subjects were examined at admission to the hospital and 1 year later using a documentation of the medical history and high-resolution magnetic resonance imaging (MRI) for the presence of depression and to determine changes in hippocampal as well as amygdala volumes. Patients were enrolled from March 2000 to August 2002.
|Method Keywords||magnetic resonance imaging (MRI)
|Result||No significant hippocampal and amygdala volume changes were observed in patients or controls between baseline and 1-year follow-up investigations. However, the subgroup of patients who were nonremitted at the time of the follow-up investigation showed significantly reduced left and right hippocampal volumes at both baseline and the 1-year follow-up compared with remitted patients. Moreover, the right hippocampal volumes of nonremitted patients were significantly smaller compared with matched healthy controls.
|Conclusions||These results do not support the hypothesis that hippocampal volumes diminish during the 1-year follow-up period. However, smaller hippocampal volumes may be related to a poor clinical outcome after 1 year.
Relationships reported by Frodl, 2004