MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Kaymak, 2010 PubMed
Full Info	Kaymak, S.U., Demir, B., Senturk, S., Tatar, I., Aldur, M.M. and Ulug, B. (2010) Hippocampus, glucocorticoids and neurocognitive functions in patients with first-episode major depressive disorders. Eur Arch Psychiatry Clin Neurosci, 260, 217-223.

Study

Hypothesis or Background	The aim of this study was to determine whether there was any relationship between hippocampal volume, and glucocorticoid regulation, and cognitive dysfunctions in drug-naive major depressive disorder (MDD) patients during their first episode.
Sample Information	Twenty drug-free female MDD patients in their first episode and 15 healthy females as control subjects were included in the study.
Method Detail	All subjects underwent 3.0 Tesla (T) magnetic resonance imaging (MRI), comprehensive neuropsychological testing and dexamethasone suppression tests (DST).
Method Keywords	magnetic resonance imaging (MRI); neuropsychological test
Result	The volumes of the right and left hippocampus of the patients were found to be significantly smaller than those of the controls. Patients were found to have significantly lower scores on measures of attention, working memory, psychomotor speed, executive functions, and visual and verbal memory fields. The performance of the patients only in the recollection memory and memory of reward-associated rules were positively correlated with hippocampal volumes. The volumes of the left and right hippocampus did not correlate with basal or post-dexamethasone cortisol levels.
Conclusions	Our findings indicate that depressed patients have smaller hippocampi even in the earlier phase of their illness. Further research efforts are needed to explain the mechanisms that are responsible for the small hippocampus in depressed patients.

Relationships reported by Kaymak, 2010

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
MDD	syndrome	Working memory (working memory)	cognition and behavior		Patients were found to have significantly lower scores on measures of attention, working memory, psychomotor speed, executive functions, and visual and verbal memory fields.	Positive
MDD	syndrome	Verbal memory (verbal memory)	cognition and behavior		Patients were found to have significantly lower scores on measures of attention, working memory, psychomotor speed, executive functions, and visual and verbal memory fields.	Positive
MDD	syndrome	Visual memory (visual memory)	cognition and behavior		Patients were found to have significantly lower scores on measures of attention, working memory, psychomotor speed, executive functions, and visual and verbal memory fields.	Positive
MDD	syndrome	Psychomotor performance (psychomotor speed)	cognition and behavior		Patients were found to have significantly lower scores on measures of attention, working memory, psychomotor speed, executive functions, and visual and verbal memory fields.	Positive
MDD	syndrome	Executive functions (executive functions)	cognition and behavior		Patients were found to have significantly lower scores on measures of attention, working memory, psychomotor speed, executive functions, and visual and verbal memory fields.	Positive
MDD	syndrome	Attention (attention)	cognition and behavior		Patients were found to have significantly lower scores on measures of attention, working memory, psychomotor speed, executive functions, and visual and verbal memory fields.	Positive
MDD	syndrome	Hippocampus (hippocampus)	brain morphology and function		The volumes of the right and left hippocampus of the patients were found to be significantly smaller than those of the controls.	Positive
Memory (memory)	cognition and behavior	Hippocampus (hippocampus)	brain morphology and function		The performance of the patients only in the recollection memory and memory of reward-associated rules were positively correlated with hippocampal volumes.	Positive