Gene Report

Basic Information

Approved Symbol	RORC
Approved Name	RAR-related orphan receptor C
Symbol Alias	RZRG, RORG, NR1F3, TOR
Location	1q21
Position	chr1:151778547-151804348 (-)
External Links	Entrez Gene: 6097 Ensembl: ENSG00000143365 UCSC: uc001ezh.3 HGNC ID: 10260
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RORC and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RORgammat (retinoic acid-related orphan receptor-gammat)	Chen, 2010	patients and normal controls		A higher level of RORgammat (retinoic acid-related orphan re...... A higher level of RORgammat (retinoic acid-related orphan receptor-gammat, the specific transcription factor of Th17 cell) mRNA expression in peripheral blood lymphocytes was found in patient. More...

Positive relationships between RORC and other components at different levels (count: 0)

Positive relationship network of RORC in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RORC and MDD (count: 0)

Negative relationships between RORC and other components at different levels (count: 0)

RORC related SNPs in MK4MDD (count: 0)

RORC related proteins in MK4MDD (count: 0)

RORC related GO terms (count: 14)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0043565	sequence-specific DNA binding	molecular function	IEA
GO:0048535	lymph node development	biological process	IEA
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	molecular function	IEA
GO:0003707	steroid hormone receptor activity	molecular function	IEA
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS
GO:0003677	DNA binding	molecular function	TAS[7811290]
GO:0008270	zinc ion binding	molecular function	IEA
GO:0033077	T cell differentiation in thymus	biological process	IEA
GO:0030522	intracellular receptor mediated signaling pathway	biological process	TAS[7811290]
GO:0072539	T-helper 17 cell differentiation	biological process	IEA
GO:0010467	gene expression	biological process	TAS
GO:0006468	protein phosphorylation	biological process	IEA
GO:0005654	nucleoplasm	cellular component	TAS
GO:0048537	mucosal-associated lymphoid tissue development	biological process	IEA

RORC related KEGG pathways (count: 0)

RORC related BioCarta pathways (count: 0)

RORC related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_71	gene expression	Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More...
REACT_15525	nuclear receptor_transcription_pathway	A classic example of bifunctional transcription factors is t...... A classic example of bifunctional transcription factors is the family of Nuclear Receptor ). For example, binding of thyroid hormone (TH) to the human TH Receptor (THRA or THRB) was found to result in the recruitment of a specific complex of Thyroid Receptor Associated Proteins - the TRAP coactivator complex - of which the TRAP220 subunit was later identified to be the Mediator 1 (MED1) homologue. Similarly, binding of Vitamin D to the human Vitamin D3 Receptor was found to result in the recruitment of a specific complex of D Receptor Interacting Proteins - the DRIP coactivator complex, of which the DRIP205 subunit was later identified to be human MED1. More...

RORC related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RORC	EIF4EBP1	No	in vitro	10405182
RORC	NCOA6	No	yeast 2-hybrid	15604093
RORC	CHD4	No	in vitro;yeast 2-hybrid	15144897

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways