Study Report
Reference
| Citation | Ballard, 2002 PubMed |
| Full Info | Ballard, C., Johnson, M., Piggott, M., Perry, R., O'Brien, J., Rowan, E., Perry, E., Lantos, P., Cairns, N. and Holmes, C. (2002) A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies. J Affect Disord, 69, 219-223.
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Study
| Hypothesis or Background |
Depression is a common and distressing problem in the context of dementia, and is significantly more common in Dementia with Lewy bodies (DLB) than in Alzheimer's disease. The neurochemical basis for depression in DLB has not been investigated. AIM: To investigate the association between depression and 5HT transporter re-uptake binding in DLB patients.
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| Sample Information | Twenty-one cases were evaluated neurochemically, of whom seven had experienced a major depressive disorder. |
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| Method Detail | A representative cohort of dementia patients received annual assessments, which included a standardised evaluation of depression until death. At post-mortem, (3H) cyanoimipramine autoradiography was used to quantify 5HT transporter re-uptake sites in the hippocampus and adjacent temporal cortex (Brodmann Area-BA 36, and 20); and parietal neocortex (BA 7a). |
| Method Keywords | clinical test |
| Result | Twenty-one cases were evaluated neurochemically, of whom seven had experienced a major depressive disorder. Major depression was associated with a significant preservation of 5HT transporter re-uptake sites in the parietal neocortex compared with non-affected cases (BA 7a area 1 t = 3.3, P = 0.004; BA 7a area 3 t = 3.8, P = 0.001). |
| Conclusions | This preliminary report is important in challenging some of the assumptions about cortical monoamine functioning in depressed dementia. |
Relationships reported by
Ballard, 2002
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Sodium-dependent serotonin transporter (5HT transporter) |
protein |
P-value<0.01 |
Major depression was associated with a significant preservation of 5HT transporter re-uptake sites in the parietal neocortex compared with non-affected cases (BA 7a area 1 t = 3.3, P = 0.004; BA 7a area 3 t = 3.8, P = 0.001). |
Positive
|
|
MDD
|
syndrome |
Parietal Lobe (parietal neocortex) |
brain morphology and function |
BA 7a area 1 t = 3.3, P-value = 0.004; BA 7a area 3 t = 3.8, P-value = 0.001 |
Major depression was associated with a significant preservation of 5HT transporter re-uptake sites in the parietal neocortex compared with non-affected cases (BA 7a area 1 t = 3.3, P = 0.004; BA 7a area 3 t = 3.8, P = 0.001). |
Positive
|
